Document Detail


Imaging the efficacy of anti-inflammatory liposomes in a rabbit model of atherosclerosis by non-invasive imaging.
MedLine Citation:
PMID:  22449928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nanomedicine can provide a potent alternative to current therapeutic strategies for atherosclerosis. For example, the encapsulation of anti-inflammatory drugs into liposomes improves their pharmacokinetics and biodistribution, thereby enhancing bioavailability to atherosclerotic plaques and improving therapeutic efficacy. The evaluation of this type of experimental therapeutics can greatly benefit from in vivo evaluation to assess biological changes, which can be performed by non-invasive imaging techniques, such as ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Here, we will illustrate the methods for inducing atherosclerosis in a rabbit model, the production of anti-inflammatory liposomes and monitoring of therapeutic efficacy of experimental therapeutics with the above-mentioned imaging techniques.
Authors:
Mark E Lobatto; Claudia Calcagno; Josbert M Metselaar; Gert Storm; Erik S G Stroes; Zahi A Fayad; Willem J M Mulder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods in enzymology     Volume:  508     ISSN:  1557-7988     ISO Abbreviation:  Meth. Enzymol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-27     Completed Date:  2012-07-23     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0212271     Medline TA:  Methods Enzymol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  211-28     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Balloon
Animals
Anti-Inflammatory Agents / therapeutic use*
Atherosclerosis / drug therapy*,  pathology
Disease Models, Animal*
Liposomes*
Magnetic Resonance Imaging
Multimodal Imaging
Positron-Emission Tomography
Rabbits
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
HHSN268201000045C/HL/NHLBI NIH HHS; HHSN268201000045C//PHS HHS; R01 CA155432/CA/NCI NIH HHS; R01 CA155432/CA/NCI NIH HHS; R01 EB009638/EB/NIBIB NIH HHS; R01 EB009638/EB/NIBIB NIH HHS; R01 HL071021/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Liposomes
Comments/Corrections

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