| Imaging and dosimetry of 99mTc EC annexin V: preliminary clinical study targeting apoptosis in breast tumors. | |
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MedLine Citation:
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PMID: 18308577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use (99m)Tc EC-annexin V to image tumor cells undergoing apoptosis. METHODS: In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering (99m)Tc EC-annexin V. RESULTS: Nine of the 10 cases showed detectable (99m)Tc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment. CONCLUSIONS: Apoptosis can be quantified using (99m)Tc EC-annexin V. |
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Authors:
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Hiroaki Kurihara; David J Yang; Massimo Cristofanilli; William D Erwin; Dong-Fang Yu; Saady Kohanim; Richard Mendez; E Edmund Kim |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-01-26 |
Journal Detail:
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Title: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Volume: 66 ISSN: 0969-8043 ISO Abbreviation: Appl Radiat Isot Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2008-10-03 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 9306253 Medline TA: Appl Radiat Isot Country: England |
Other Details:
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Languages: eng Pagination: 1175-82 Citation Subset: IM |
Affiliation:
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Department of Experimental Diagnostic Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Annexin A5 / chemical synthesis, diagnostic use* Apoptosis* / drug effects Breast Neoplasms / diagnosis*, pathology Female Humans Middle Aged Organotechnetium Compounds / chemical synthesis, diagnostic use* Prospective Studies Radiometry Radiopharmaceuticals / chemical synthesis, diagnostic use Tomography, Emission-Computed, Single-Photon / methods |
| Grant Support | |
ID/Acronym/Agency:
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CA 16672/CA/NCI NIH HHS; P50 CA116199-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Annexin A5; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m ethylenedicysteine annexin V |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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