Document Detail


Imaging of dialysis-related amyloid (AB-amyloid) deposits with 131I-beta 2-microglobulin.
MedLine Citation:
PMID:  2074658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The diagnosis of dialysis-related amyloid (AB-amyloid) has been based usually on clinical and radiological criteria. Following the discovery that beta 2-microglobulin was the major protein of this amyloid, we isolated and radiolabelled uremic plasma beta 2-microglobulin. After intravenous injection, gamma-camera images of selected joint areas were obtained from 42 patients who were on regular hemodialysis therapy. Positive scans involving the shoulder, hip, knee and carpal regions were found in 13 of 14 patients treated for more than 10 years and 10 of 16 patients treated for 5 to 10 years. Patients treated for less time had negative scans. Specificity was indicated by negative scans in non-amyloid inflammatory lesions in control hemodialysis patients. Up to 48-fold tracer enrichment was detected in excised AB-amyloid containing tissue as compared to amyloid-free tissue. These findings suggest that circulating radiolabelled beta 2-microglobulin is taken up by the amyloid deposits. This method may non-invasively detect tissue infiltrates of amyloid. It may also permit prospective evaluation of the efficacy of prophylactic dialysis strategies which are designed to prevent or delay the onset of this complication of long-term dialysis.
Authors:
J Floege; W Burchert; A Brandis; P Gielow; B Nonnast-Daniel; E Spindler; H Hundeshagen; S Shaldon; K M Koch
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  38     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-04-18     Completed Date:  1991-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1169-76     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Medizinische Hochschule Hannover, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Amyloidosis / etiology,  radionuclide imaging*
Female
Humans
Iodine Radioisotopes / diagnostic use*
Joint Diseases / etiology,  radionuclide imaging*
Male
Middle Aged
Renal Dialysis / adverse effects*
beta 2-Microglobulin / diagnostic use*
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/beta 2-Microglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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