| Imaging coronary and extracoronary atherosclerosis: feasibility and impact of whole-body computed tomography angiography. | |
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MedLine Citation:
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PMID: 19277677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A comprehensive whole-body approach to noninvasive evaluation of coronary and extracoronary vasculature is currently not available. The objective of our study was to assess the potential of 64-slice computed tomography angiography (64-CTA) for whole-body evaluation of atherosclerosis burden. Seventy-eight patients referred for coronary imaging underwent whole-body 64-CTA using an adjusted strategy for the administration of contrast medium with dose-saving algorithms involving ECG modulation and reduced tube voltage. Arterial segments (15 coronary, 32 systemic) were evaluated for significant (> or =50%) steno-occlusive disease while arterovenous density was evaluated at seven extracoronary locations. Homogeneous attenuation (mean 321 +/- 20 HU) was obtained throughout the systemic vasculature. Atherosclerosis was observed in 238/995 (24%) coronary and 368/2441 (15%) systemic segments. Significant stenoses/occlusions were present in 214 (21%)/24 (2.5%) coronary segments while asymptomatic clinically relevant stenoses were present in 49 systemic segments. Sensitivity, specificity, positive and negative predictive values of coronary 64-CTA among 52 patients who also underwent quantitative coronary angiography were 92%, 95%, 81% and 98%, respectively. ECG modulation decreased radiation exposure to 14.1-15.4 mSv per patient. Comprehensive, noninvasive assessment of atherosclerosis can be performed by whole-body 64-CTA and may have a positive impact on secondary prevention. |
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Authors:
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Alessandro Napoli; Carlo Catalano; Marco Francone; Vincenzo Sciacca; Iacopo Carbone; Cesare Greco; Michele Anzidei; Francesca Antonella Calabrese; Beatrice Cavallo Marincola; Miles A Kirchin; Annarita Vestri; Marcello Arca; Luigi Iuliano; Roberto Passariello |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2009-03-11 |
Journal Detail:
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Title: European radiology Volume: 19 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-05 Completed Date: 2009-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 1704-14 Citation Subset: IM |
Affiliation:
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Cardiovascular Imaging Unit, Department of Radiological Sciences, Sapienza University of Rome, Viale Regina Elena, 324, 00184, Rome, Italy. alessandro.napoli@uniroma1.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiography
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methods* Atherosclerosis / radiography* Feasibility Studies Female Humans Male Radiographic Image Enhancement / methods Radiographic Image Interpretation, Computer-Assisted / methods* Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* Whole Body Imaging / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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