| Imaging characteristics following (90) yttrium microsphere treatment for unresectable liver cancer. | |
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MedLine Citation:
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PMID: 21501398 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Selective internal radiation therapy (SIRT) with (90) yttrium microspheres - also known as radioembolisation - is a relatively new interventional radiology technique offering symptomatic and survival advantages for patients with unresectable liver cancer. However, in delivering both beta-particle brachytherapy and embolisation of tumour vasculature, SIRT produces biological sequelae and imaging characteristics distinct from other treatment modalities. Current CT interpretation criteria consistently under-report pathological responses to radioembolisation, diminishing both the prognosis and subsequent treatment choices for responding patients. However, newer criteria incorporating both tumour dimensions and enhancement characteristics improve the correlation with histopathology and provide substantially earlier confirmation of response. CT following radioembolisation may also identify parenchymal features that are often benign but may be mistaken for tumour progression. This review outlines imaging criteria specific to SIRT, including assessment of tumour response and interpretation of both lesion and parenchymal characteristics. The adjunctive role of additional modalities such as positron emission tomography is also addressed. |
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Authors:
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Lourens Bester; Peter G Hobbins; Shih-Chang Wang; Riad Salem |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medical imaging and radiation oncology Volume: 55 ISSN: 1754-9485 ISO Abbreviation: J Med Imaging Radiat Oncol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101469340 Medline TA: J Med Imaging Radiat Oncol Country: Australia |
Other Details:
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Languages: eng Pagination: 111-8 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Journal of Medical Imaging and Radiation Oncology © 2011 The Royal Australian and New Zealand College of Radiologists. |
Affiliation:
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Department of Radiology, St Vincent's Public Hospital, Darlinghurst, Sydney, New South Wales, Australian Venom Research Unit, Department of Pharmacology, University of Melbourne, Melbourne, Victoria, and Department of Diagnostic Radiology, University of Sydney, Sydney, New South Wales, Australia; and Department of Radiology, Oncology and Surgery, Northwestern University, Chicago, Illinois, USA. |
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