Document Detail

Imaging characteristics of children with auditory neuropathy spectrum disorder.
MedLine Citation:
PMID:  20593543     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify and define the imaging characteristics of children with auditory neuropathy spectrum disorder (ANSD).
DESIGN: Retrospective medical records review and analysis of both temporal bone computed tomographic (CT) and magnetic resonance images (MRI) in children with a diagnosis of ANSD.
SETTING: Tertiary referral center.
PATIENTS: One hundred eighteen children with the electrophysiologic characteristics of ANSD with available imaging studies for review.
INTERVENTIONS: Two neuroradiologists and a neurotologist reviewed each study, and consensus descriptions were established.
MAIN OUTCOME MEASURES: The type and number of imaging findings were tabulated.
RESULTS: Sixty-eight (64%) MRIs revealed at least 1 imaging abnormality, whereas selective use of CT identified 23 (55%) with anomalies. The most prevalent MRI findings included cochlear nerve deficiency (n = 51; 28% of 183 nerves), brain abnormalities (n = 42; 40% of 106 brains), and prominent temporal horns (n = 33, 16% of 212 temporal lobes). The most prevalent CT finding from selective use of CT was cochlear dysplasia (n = 13; 31%).
CONCLUSION: Magnetic resonance imaging will identify many abnormalities in children with ANSD that are not readily discernable on CT. Specifically, both developmental and acquired abnormalities of the brain, posterior cranial fossa, and cochlear nerves are not uncommonly seen in this patient population. Inner ear anomalies are well delineated using either imaging modality. Because many of the central nervous system findings identified in this study using MRI can alter the treatment and prognosis for these children, we think that MRI should be the initial imaging study of choice for children with ANSD.
Joseph P Roche; Benjamin Y Huang; Mauricio Castillo; Marc K Bassim; Oliver F Adunka; Craig A Buchman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology     Volume:  31     ISSN:  1537-4505     ISO Abbreviation:  Otol. Neurotol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2010-10-08     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  100961504     Medline TA:  Otol Neurotol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  780-8     Citation Subset:  IM    
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MeSH Terms
Brain / abnormalities,  pathology,  radiography
Central Nervous System / abnormalities
Cochlea / abnormalities,  pathology,  radiography
Cochlear Nerve / pathology*,  radiography
Hearing Disorders / pathology
Magnetic Resonance Imaging
Peripheral Nervous System Diseases / pathology*,  radiography
Temporal Bone / pathology,  radiography
Tomography, X-Ray Computed
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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