| Imaging of cerebral blood flow and metabolism. | |
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MedLine Citation:
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PMID: 16960477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To review the techniques for imaging cerebral blood flow and metabolism following injury to the brain. RECENT FINDINGS: Xenon enhanced computerized tomography (Xenon CT), CT perfusion and single photon emission CT provide measurements of cerebral perfusion, while positron emission tomography (PET), and magnetic resonance imaging and spectroscopy (MRI and MRS) are able to assess both perfusion and cerebral metabolism. Xenon CT and CT perfusion are readily available and have proved useful in a variety of causes of brain injury. PET is an extremely useful research tool for defining cerebral physiology, but is limited in its availability. Despite the continuing development of MRI and MRS imaging, the scanning environment remains hostile for critically ill patients, and further research is required before the techniques become generally available. SUMMARY: Imaging of cerebral blood flow and metabolism has been shown to be useful following a variety of causes of brain injury, as it can help to define the cause and extent of injury, identify appropriate treatments and predict outcome. Imaging based on CT techniques (Xenon CT and CT perfusion) can be implemented easily in most hospital centres, and are able to provide quantitative perfusion data in addition to structural images. |
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Authors:
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Jonathan P Coles |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in anaesthesiology Volume: 19 ISSN: 0952-7907 ISO Abbreviation: Curr Opin Anaesthesiol Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-08 Completed Date: 2007-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8813436 Medline TA: Curr Opin Anaesthesiol Country: United States |
Other Details:
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Languages: eng Pagination: 473-80 Citation Subset: IM |
Affiliation:
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University Department of Anaesthesia, Addenbrooke's Hospital, Cambridge, UK. jpc44@wbic.cam.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Circulation Time Brain / blood supply*, metabolism* Brain Diseases / diagnosis*, metabolism, radiography, radionuclide imaging Cerebrovascular Circulation Diffusion Magnetic Resonance Imaging Fluorodeoxyglucose F18 / diagnostic use Glucose / metabolism Humans Magnetic Resonance Imaging* / methods Magnetic Resonance Spectroscopy* / methods Organotechnetium Compounds / diagnostic use Oxygen / metabolism Oxygen Radioisotopes / diagnostic use Perfusion Positron-Emission Tomography Radiopharmaceuticals / diagnostic use* Spin Labels Tomography, Emission-Computed, Single-Photon Tomography, Spiral Computed Tomography, X-Ray Computed* / methods Xenon / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds; 0/Oxygen Radioisotopes; 0/Radiopharmaceuticals; 0/Spin Labels; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18; 7440-63-3/Xenon; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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