Document Detail

Imaging of cerebral blood flow and metabolism.
MedLine Citation:
PMID:  16960477     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To review the techniques for imaging cerebral blood flow and metabolism following injury to the brain. RECENT FINDINGS: Xenon enhanced computerized tomography (Xenon CT), CT perfusion and single photon emission CT provide measurements of cerebral perfusion, while positron emission tomography (PET), and magnetic resonance imaging and spectroscopy (MRI and MRS) are able to assess both perfusion and cerebral metabolism. Xenon CT and CT perfusion are readily available and have proved useful in a variety of causes of brain injury. PET is an extremely useful research tool for defining cerebral physiology, but is limited in its availability. Despite the continuing development of MRI and MRS imaging, the scanning environment remains hostile for critically ill patients, and further research is required before the techniques become generally available. SUMMARY: Imaging of cerebral blood flow and metabolism has been shown to be useful following a variety of causes of brain injury, as it can help to define the cause and extent of injury, identify appropriate treatments and predict outcome. Imaging based on CT techniques (Xenon CT and CT perfusion) can be implemented easily in most hospital centres, and are able to provide quantitative perfusion data in addition to structural images.
Jonathan P Coles
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in anaesthesiology     Volume:  19     ISSN:  0952-7907     ISO Abbreviation:  Curr Opin Anaesthesiol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2007-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8813436     Medline TA:  Curr Opin Anaesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-80     Citation Subset:  IM    
University Department of Anaesthesia, Addenbrooke's Hospital, Cambridge, UK.
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MeSH Terms
Blood Circulation Time
Brain / blood supply*,  metabolism*
Brain Diseases / diagnosis*,  metabolism,  radiography,  radionuclide imaging
Cerebrovascular Circulation
Diffusion Magnetic Resonance Imaging
Fluorodeoxyglucose F18 / diagnostic use
Glucose / metabolism
Magnetic Resonance Imaging* / methods
Magnetic Resonance Spectroscopy* / methods
Organotechnetium Compounds / diagnostic use
Oxygen / metabolism
Oxygen Radioisotopes / diagnostic use
Positron-Emission Tomography
Radiopharmaceuticals / diagnostic use*
Spin Labels
Tomography, Emission-Computed, Single-Photon
Tomography, Spiral Computed
Tomography, X-Ray Computed* / methods
Xenon / diagnostic use
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Oxygen Radioisotopes; 0/Radiopharmaceuticals; 0/Spin Labels; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18; 7440-63-3/Xenon; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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