| Imaging of cancer predisposition syndromes in children. | |
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MedLine Citation:
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PMID: 21257945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The term cancer predisposition syndrome (CPS) encompasses a multitude of familial cancers in which a clear mode of inheritance can be established, although a specific gene defect has not been described in all cases. Advances in genetics and the development of new imaging techniques have led to better understanding and early detection of these syndromes and offer the potential for preclinical diagnosis of any associated tumors. As a result, imaging has become an essential component of the clinical approach to management of CPSs and the care of children suspected of having a CPS or with a confirmed diagnosis. Common CPSs in children include neurofibromatosis type 1, Beckwith-Wiedemann syndrome, multiple endocrine neoplasia, Li-Fraumeni syndrome, von Hippel-Lindau syndrome, and familial adenomatous polyposis. Radiologists should be familiar with these syndromes, their common associated tumors, the new imaging techniques that are available, and current screening and surveillance recommendations to optimize the assessment of affected children. |
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Authors:
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Johanna Monsalve; Jeevesh Kapur; David Malkin; Paul S Babyn |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Radiographics : a review publication of the Radiological Society of North America, Inc Volume: 31 ISSN: 1527-1323 ISO Abbreviation: Radiographics Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-01-24 Completed Date: 2011-05-02 Revised Date: 2011-05-17 |
Medline Journal Info:
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Nlm Unique ID: 8302501 Medline TA: Radiographics Country: United States |
Other Details:
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Languages: eng Pagination: 263-80 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Imaging, Hospital for Sick Children and University of Toronto, Toronto, Ont, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenomatous Polyposis Coli
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diagnosis Beckwith-Wiedemann Syndrome / complications, diagnosis Child Humans Li-Fraumeni Syndrome / diagnosis Magnetic Resonance Imaging* Multiple Endocrine Neoplasia Type 1 / diagnosis Neoplastic Syndromes, Hereditary / diagnosis*, genetics Neurofibromatosis 1 / diagnosis Tomography, X-Ray Computed* von Hippel-Lindau Disease / diagnosis |
| Comments/Corrections | |
Erratum In:
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Radiographics. 2011 Mar-Apr;31(2):624 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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