| Imaging brain tumors with PET, SPECT, and ultrasonography. | |
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MedLine Citation:
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PMID: 22230440 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Among various physiological and biochemical imaging modalities, positron emission tomography (PET) provides quantitative measures of energy metabolism, solute and drug transport, and cell proliferation. For clinical applications in patients with brain tumors, radiolabeled deoxyglucose ([(18)F]-2-fluoro-2-deoxy-d-glucose, FDG) and amino acids (e.g., [(11)C]methionine, O-2-[(18)F]fluoroethyl-l-tyrosine) are validated and widely available. To localize metabolic alterations accurately, particularly within heterogeneous lesions, the coregistration of PET images with structural imaging such as magnetic resonance imaging (MRI) is mandatory. In the diagnostic setting, PET with FDG allows the grading of gliomas, the detection of malignant transformation, and the differentiation of recurrent malignant glioma from radiation-induced necrosis. Amino acids are established to identify metabolically active regions within suspected low-grade gliomas that are suitable for stereotactic biopsy. Amino acids may also be used for treatment evaluation, as metabolic responses (PET) may occur several months before tumor volume reductions (MRI). Therefore, PET allows treatment decisions to be tailored for individual patients, and efficacy and safety to be optimized. With its broad range of diagnostic applications, PET is well suited to be integrated into multidisciplinary clinical trials and research protocols. |
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Authors:
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Ulrich Roelcke |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn Volume: 104 ISSN: 0072-9752 ISO Abbreviation: Handb Clin Neurol Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0166161 Medline TA: Handb Clin Neurol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 135-42 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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