| Imaging biomarkers of cardiovascular disease. | |
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MedLine Citation:
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PMID: 20815049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Current clinical techniques that rely on stenosis measurement alone appear to be insufficient for risk prediction in atherosclerosis patients. Many novel imaging methods have been developed to study atherosclerosis progression and to identify new features that can predict future clinical risk. MRI of atherosclerotic vessel walls is one such method. It has the ability to noninvasively evaluate multiple biomarkers of the disease such as luminal stenosis, plaque burden, tissue composition and plaque activity. In addition, the accuracy of in vivo MRI has been validated against histology with high reproducibility, thus paving the way for application to epidemiological studies of disease pathogenesis and, by serial MRI, in monitoring the efficacy of therapeutic intervention. In this review, we describe the various MR techniques used to evaluate aspects of plaque progression, discuss imaging-based measurements (imaging biomarkers), and also detail their validation. The application of plaque MRI in clinical trials as well as emerging imaging techniques used to evaluate plaque compositional features and biological activities are also discussed. |
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Authors:
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Jinnan Wang; Niranjan Balu; Gador Canton; Chun Yuan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2011-01-10 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 502-15 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Washington, Seattle, Washington, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Accreditation* Biological Markers Cardiovascular Diseases / diagnosis* Diagnostic Imaging / methods Education, Medical, Continuing Humans Magnetic Resonance Angiography / methods Magnetic Resonance Imaging / methods* Radiopharmaceuticals / diagnostic use United States |
| Grant Support | |
ID/Acronym/Agency:
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HL076378/HL/NHLBI NIH HHS; HL56874/HL/NHLBI NIH HHS; R01 HL056874-13/HL/NHLBI NIH HHS; R01 HL076378-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Radiopharmaceuticals |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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