| Imaging apolipoprotein AI in vivo. | |
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MedLine Citation:
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PMID: 21264979 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Coronary disease risk increases inversely with high-density lipoprotein (HDL) level. The measurement of the biodistribution and clearance of HDL in vivo, however, has posed a technical challenge. This study presents an approach to the development of a lipoprotein MRI agent by linking gadolinium methanethiosulfonate (Gd[MTS-ADO3A]) to a selective cysteine mutation in position 55 of apo AI, the major protein of HDL. The contrast agent targets both liver and kidney, the sites of HDL catabolism, whereas the standard MRI contrast agent, gadolinium-diethylenetriaminepentaacetic acid-bismethylamide (GdDTPA-BMA, gadodiamide), enhances only the kidney image. Using a modified apolipoprotein AI to create an HDL contrast agent provides a new approach to investigate HDL biodistribution, metabolism and regulation in vivo. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Renuka Sriram; Jens O Lagerstedt; Jitka Petrlova; Haris Samardzic; Ulrike Kreutzer; Hongtao Xie; George A Kaysen; Jean F Desreux; David Thonon; Vincent Jacques; Martha Van Loan; John C Rutledge; Michael N Oda; John C Voss; Thomas Jue |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-24 |
Journal Detail:
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Title: NMR in biomedicine Volume: - ISSN: 1099-1492 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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