| Imaging analysis of the brain in a primate model of cerebral malaria. | |
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MedLine Citation:
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PMID: 19467218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper reviews our studies concerning imaging analysis of the brain in a primate model of cerebral malaria. To elucidate the clinical features of cerebral malaria, we performed positron emission tomography with (18)F-fluorodeoxyglucose (FDG-PET) scanning and magnetic resonance imaging (MRI) of the brain in Japanese macaques (Macaca fuscata) infected with Plasmodium coatneyi, a primate model of severe human malaria with cerebral involvement. On FDG-PET scanning, we observed diffuse and heterogeneous reduction of metabolism in the cerebral cortex in the acute phase of malaria infection. Although the monkey exhibited severe clinical signs, MR imaging did not reveal any significant changes during the course of infection. Histopathologic examination frequently revealed preferential sequestration of PRBCs in the cerebral and cerebellum capillaries, but neither parenchymal injury nor neuronal necrosis was found in the tissues. These results suggest that heterogeneous metabolic reduction and lack of abnormalities on MRI in the acute phase of CM may be due to any avoidance mechanisms from ischemia caused by sequestration. This may be one reason why more than half of CM patients have no neurological sequelae following recovery. |
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Authors:
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Satoru Kawai; Munehiro Sugiyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-05-23 |
Journal Detail:
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Title: Acta tropica Volume: 114 ISSN: 1873-6254 ISO Abbreviation: Acta Trop. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370374 Medline TA: Acta Trop Country: Netherlands |
Other Details:
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Languages: eng Pagination: 152-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Center for Tropical Medicine and Parasitology, Dokkyo Medical University, Mibu, Tochigi, Japan. skawai@dokkyomed.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / parasitology, pathology*, radiography* Disease Models, Animal Histocytochemistry Image Processing, Computer-Assisted Macaca Magnetic Resonance Imaging Malaria, Cerebral / pathology* Plasmodium / pathogenicity Positron-Emission Tomography |
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