Document Detail

Imaging amoeboid cancer cell motility in vivo.
MedLine Citation:
PMID:  18754999     Owner:  NLM     Status:  MEDLINE    
The availability of multi-photon intravital microscopy has recently allowed researchers to start to visualise the dynamic behaviour of cancer cells in vivo. This imaging has revealed that many cancer cells ranging from carcinoma to melanoma move in an amoeboid manner in order to invade surrounding tissue and escape from the primary tumour. This mode on cell motility is extremely rapid and does not require the activity of proteases to degrade the extra-cellular matrix (ECM). This review details the techniques that are available to study cell motility in vivo and discusses the current knowledge about the mechanisms of amoeboid cell motility.
S Pinner; E Sahai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of microscopy     Volume:  231     ISSN:  1365-2818     ISO Abbreviation:  J Microsc     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-29     Completed Date:  2008-11-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0204522     Medline TA:  J Microsc     Country:  England    
Other Details:
Languages:  eng     Pagination:  441-5     Citation Subset:  IM    
Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, LONDON WC2A 3PX, United Kingdom.
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MeSH Terms
Cell Physiological Phenomena*
Microscopy / methods*
Grant Support
//Cancer Research UK

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