| Imaging amoeboid cancer cell motility in vivo. | |
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MedLine Citation:
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PMID: 18754999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The availability of multi-photon intravital microscopy has recently allowed researchers to start to visualise the dynamic behaviour of cancer cells in vivo. This imaging has revealed that many cancer cells ranging from carcinoma to melanoma move in an amoeboid manner in order to invade surrounding tissue and escape from the primary tumour. This mode on cell motility is extremely rapid and does not require the activity of proteases to degrade the extra-cellular matrix (ECM). This review details the techniques that are available to study cell motility in vivo and discusses the current knowledge about the mechanisms of amoeboid cell motility. |
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Authors:
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S Pinner; E Sahai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of microscopy Volume: 231 ISSN: 1365-2818 ISO Abbreviation: J Microsc Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-29 Completed Date: 2008-11-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0204522 Medline TA: J Microsc Country: England |
Other Details:
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Languages: eng Pagination: 441-5 Citation Subset: IM |
Affiliation:
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Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, LONDON WC2A 3PX, United Kingdom. Sophie.Pinner@cancer.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Physiological Phenomena* Locomotion* Microscopy / methods* Neoplasms* |
| Grant Support | |
ID/Acronym/Agency:
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//Cancer Research UK |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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