| Imaging of vascular inflammation with [11C]-PK11195 and positron emission tomography/computed tomography angiography. | |
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MedLine Citation:
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PMID: 20705222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to investigate whether positron emission tomography/computed tomography (CT) angiography using [11C]-PK11195, a selective ligand for peripheral benzodiazepine receptors expressed in activated macrophages, can be used to image vascular inflammation. BACKGROUND: Activated macrophages and T lymphocytes are fundamental elements in the pathogenesis of large-vessel vasculitides. METHODS: Fifteen patients (age 52+/-16 years) with systemic inflammatory disorders (6 consecutive symptomatic patients with clinical suspicion of active vasculitis and 9 asymptomatic control patients) underwent positron emission tomography with [11C]-PK11195 and CT angiography. [11C]-PK11195 uptake was measured by calculating target-to-background ratios of activity normalized to venous blood. RESULTS: Coregistration of positron emission tomography with contrast-enhanced CT angiography facilitated localization of [11C]-PK11195 arterial wall uptake. Visual analysis revealed focal [11C]-PK11195 uptake in the arterial wall of all 6 symptomatic patients, but in none of the asymptomatic controls. Although serum inflammatory biomarkers (C-reactive protein, erythrocyte sedimentation rate, white cell count) did not differ significantly between the 2 groups, symptomatic patients had increased [11C]-PK11195 vascular uptake (target-to-background ratio 2.41+/-1.59 vs. 0.98+/-0.10; p=0.001). CONCLUSIONS: By binding to activated macrophages in the vessel wall, [11C]-PK11195 enables noninvasive imaging of vascular inflammation. Alternative longer-lived radioligands for probing peripheral benzodiazepine receptors are being tested for wider clinical applications. |
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Authors:
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Francesca Pugliese; Oliver Gaemperli; Anne R Kinderlerer; Frederic Lamare; Joseph Shalhoub; Alun Huw Davies; Ornella E Rimoldi; Justin C Mason; Paolo G Camici |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 56 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-13 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 653-61 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Medical Research Council Clinical Sciences Centre and National Heart and Lung Institute, Imperial College, and Hammersmith Hospital, London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiography* Arteries / radionuclide imaging Carbon Radioisotopes / diagnostic use* Female Giant Cell Arteritis / radiography, radionuclide imaging Humans Image Processing, Computer-Assisted Isoquinolines / diagnostic use*, pharmacokinetics Lupus Erythematosus, Systemic / radiography, radionuclide imaging Macrophages / metabolism Male Middle Aged Positron-Emission Tomography* Radiopharmaceuticals / diagnostic use* Receptors, GABA-A / metabolism Takayasu Arteritis / radiography, radionuclide imaging Tomography, X-Ray Computed* Vasculitis / radiography*, radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Isoquinolines; 0/Radiopharmaceuticals; 0/Receptors, GABA-A; 85340-56-3/PK 11195 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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