Document Detail


Imaging mass spectrometry in neuroscience.
MedLine Citation:
PMID:  23530951     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Imaging mass spectrometry is an emerging technique of great potential for investigating the chemical architecture in biological matrices. Although the potential for studying neurobiological systems is evident, the relevance of the technique for application in neuroscience is still in its infancy. In the present Review, a principal overview of the different approaches, including matrix assisted laser desorption ionization and secondary ion mass spectrometry, is provided with particular focus on their strengths and limitations for studying different neurochemical species in situ and in vitro. The potential of the various approaches is discussed based on both fundamental and biomedical neuroscience research. This Review aims to serve as a general guide to familiarize the neuroscience community and other biomedical researchers with the technique, highlighting its great potential and suitability for comprehensive and specific chemical imaging.
Authors:
Jörg Hanrieder; Nhu T N Phan; Michael E Kurczy; Andrew G Ewing
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-04-30
Journal Detail:
Title:  ACS chemical neuroscience     Volume:  4     ISSN:  1948-7193     ISO Abbreviation:  ACS Chem Neurosci     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-07-18     Completed Date:  2013-10-22     Revised Date:  2014-05-16    
Medline Journal Info:
Nlm Unique ID:  101525337     Medline TA:  ACS Chem Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  666-79     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry*
Humans
Mass Spectrometry / methods*
Neurotransmitter Agents / analysis*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
Spectrometry, Mass, Secondary Ion / methods
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents
Comments/Corrections

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