Document Detail


Imaging Escherichia coli using functionalized core/shell CdSe/CdS quantum dots.
MedLine Citation:
PMID:  16724226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The internalization of a series of water-soluble CdSe/CdS quantum dots (QDs) stabilized by citrate, isocitrate, succinate, and malate by Escherichia coli is established by epifluorescence and confocal fluorescence scanning microscopy, fluorimetry, and UV-vis spectroscopy on whole and lysed bacterial cells. The organic-acid-stabilized QDs span a range in size from 3.8+/-1.1 to 6.0+/-2.4 nm with emission wavelengths from 540 to 630 nm. QDs of different sizes (i.e., 3.8-6 nm) can enter the bacterium and be detected on different fluorescence channels with little interference from other QDs as a result of the distinct emission profiles (i.e., 540-630 nm, respectively). Costaining QD-labeled E. coli with 4',6-diamidino-2-phenylindole dihydrochloride (DAPI) demonstrates that the QDs and DAPI are colocalized within E. coli, whereas costaining QD-labeled E. coli with membrane dye FM4-64 shows that the FM4-64 is localized in the outer bacterial membrane and that the QDs are inside.
Authors:
Matthew D Hirschey; Yong-Jin Han; Galen D Stucky; Alison Butler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-05-25
Journal Detail:
Title:  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry     Volume:  11     ISSN:  0949-8257     ISO Abbreviation:  J. Biol. Inorg. Chem.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-22     Completed Date:  2006-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9616326     Medline TA:  J Biol Inorg Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  663-9     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA.
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MeSH Terms
Descriptor/Qualifier:
Cadmium Compounds / metabolism*
Escherichia coli / cytology*,  metabolism
Microscopy, Confocal
Quantum Dots*
Selenium Compounds / metabolism*
Staining and Labeling / methods*
Sulfides / metabolism*
Grant Support
ID/Acronym/Agency:
GM38130/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Cadmium Compounds; 0/Selenium Compounds; 0/Sulfides; 1306-23-6/cadmium sulfide; 1306-24-7/cadmium selenide

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