| Imaging Corticospinal Degeneration in Neonatal Rats with Unilateral Cerebral Infarction. | |
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MedLine Citation:
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PMID: 21223967 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Recent human studies indicate that magnetic resonance (MR) imaging, particularly diffusion weighted imaging, detects abnormalities within the descending cortico-spinal tract following stroke. Whether these changes are directly related to processes of axonal degeneration and how MR changes (e.g. apparent diffusion coefficient of water (ADC) and T(2)) vary in their diagnostic utility over time is not known. The present study demonstrates that a commonly used rat model of neonatal transient unilateral hypoxia-ischemia provides similar diffusion weighted and ADC changes in the cerebral peduncle as those observed in human neonates clinically. Imaging the descending cortico-spinal tract in this model at defined acute (1-3days) and chronic (1 and 4weeks) time points demonstrates increased T(2) and progressive changes in ADC within the descending cortico-spinal tract in the first days to weeks following hypoxia-ischemia with a normalization by 1week and further increases in ispilateral cerebral cortex by 4weeks. These imaging changes are associated with reduced axonal neurofilament staining both at the subacute and more chronic time points. This demonstrates directly the utility of ADC and T(2) MRI to detect acute changes in axons associated with early Wallerian degeneration. |
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Authors:
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S Lama; M Qiao; A Kirton; S Sun; E Cheng; T Foniok; U I Tuor |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-9 |
Journal Detail:
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Title: Experimental neurology Volume: - ISSN: 1090-2430 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-2-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Medical Science, Faculty of Medicine, University of Calgary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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