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Imaging Cardiac Activation Sequence during Ventricular Tachycardia in a Canine Model of Nonischemic Heart Failure.
MedLine Citation:
PMID:  25416188     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Introduction: Noninvasive cardiac activation imaging of ventricular tachycardia (VT) is important in the clinical diagnosis and treatment of arrhythmias in heart failure (HF) patients. This study investigated the ability of the three-dimensional cardiac electrical imaging (3DCEI) technique for charactering the activation patterns of spontaneously-occurring and norepinephrine (NE) induced VTs in a newly-developed arrhythmogenic canine model of nonischemic HF. Methods: HF was induced by aortic insufficiency followed by aortic constriction in three canines. Up to 128 body-surface ECGs were measured simultaneously with bipolar recordings from up to 232 intramural sites in a closed-chest condition. Data analysis was performed on the spontaneously-occurring VTs (n=4) and the NE-induced nonsustained VTs (n=8) in HF canines. Results: Both spontaneously-occurring and NE-induced nonsustained VTs initiated by a focal mechanism primarily from the subendocardium, but occasionally from the subepicardium of left ventricle. Most focal initiation sites were located at apex, right ventricular outflow tract and left lateral wall. The NE-induced VTs were longer, more rapid, and had more focal sites than the spontaneously-occurring VTs. Good correlation was obtained between imaged activation sequence and direct measurements (averaged correlation coefficient of ~0.70 over 135 VT beats). The reconstructed initiation sites were ~10 mm from measured initiation sites, suggesting good localization in such a large animal model with cardiac size similar to human. Conclusions: Both spontaneously-occurring and NE-induced nonsustained VTs had focal initiation in this canine model of nonischemic HF. 3DCEI is feasible to image the activation sequence and help define arrhythmia mechanism of nonischemic HF-associated VTs.
Authors:
Chengzong Han; Steven M Pogwizd; Long Yu; Zhaoye Zhou; Cheryl R Killingsworth; Bin He
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-21
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-22     Completed Date:  -     Revised Date:  2014-11-25    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  ajpheart.00196.2014     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Journal of Physiology - Heart and Circulatory Physiology.
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