Document Detail

Image-guided robotic radiosurgery in a rat glioma model.
MedLine Citation:
PMID:  15578338     Owner:  NLM     Status:  MEDLINE    
Despite the proven efficacy of radiosurgery for the treatment of brain tumors, limited histological information is available after treatment that might allow a better understanding of the relationship between radiation dose, the volume treated, and the response of the surrounding brain to the delivered radiation. The use of an animal model could provide the opportunity to clarify these relationships and answer several other key questions arising in clinical practice. We show here that treatment of small animals with radiosurgery is feasible using a robotically controlled linear accelerator, which offers the advantages of radiosurgery and preserves the potential for fractionated regimens without rigid immobilization. Specifically, we demonstrate the use of a robotically driven linear accelerator to provide radiosurgical treatment to a rat brain tumor model.
T G Psarros; B Mickey; K Gall; J Gilio; J Delp; C White; J Drees; M Willis; D Pistemmna; C A Giller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Minimally invasive neurosurgery : MIN     Volume:  47     ISSN:  0946-7211     ISO Abbreviation:  Minim Invasive Neurosurg     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-12-03     Completed Date:  2005-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9440973     Medline TA:  Minim Invasive Neurosurg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  266-72     Citation Subset:  IM    
Department of Neurosurgery, University of Texas Southwestern School of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390-8855, USA.
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MeSH Terms
Brain Neoplasms / pathology,  radiography,  surgery*
Disease Models, Animal
Gliosarcoma / pathology,  radiography,  surgery*
Radiosurgery / instrumentation*
Rats, Inbred F344
Surgery, Computer-Assisted / instrumentation*
Tomography, X-Ray Computed

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