Document Detail

Image-guided radiotherapy: rational, modalities and results
MedLine Citation:
PMID:  19211367     Owner:  NLM     Status:  MEDLINE    
The objective of Image-Guided Radiotherapy (IGRT) is to take in account the inter- or/and intrafraction anatomic variations (organ motion and deformations) in order to improve treatment accuracy. The IGRT should therefore translate in a clinical benefit the recent advances in both tumor definition thanks to functional imaging, and dose distribution thanks to intensity modulated radiotherapy. The IGRT enables direct or indirect tumor visualization during radiation delivery. If the tumor position does not correspond with the theoretical location of target derived from planning system, the table is moved. In case of important uncertainties related to target deformation, a new planning can be discussed. IGRT is realized by different types of devices which can vary in principle and as well as in their implementation: from LINAC-integrated-kV (or MV)-Cone Beam CTs to helicoidal tomotherapy, Cyberknife and Novalis low-energy stereoscopic imaging system. These techniques led to a more rational choice of Planning Target Volume. Being recently introduced in practice, the clinical results of this technique are still limited. Nevertheless, until so far, IGRT has showed promising results with reports of minimal acute toxicity. This review describes IGRT for various tumor localizations. The dose delivered by on board imaging should be taken in account. A strong quality control is required for safety and proper prospective evaluation of the clinical benefit of IGRT.
R de Crevoisier; G Louvel; G Cazoulat; J Leseur; C Lafond; K Lahbabi; C Chira; J-L Lagrange
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Bulletin du cancer     Volume:  96     ISSN:  1769-6917     ISO Abbreviation:  Bull Cancer     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-12     Completed Date:  2009-03-06     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  0072416     Medline TA:  Bull Cancer     Country:  France    
Other Details:
Languages:  fre     Pagination:  123-32     Citation Subset:  IM    
D?partement de radioth?rapie, centre Eug?ne-Marquis, avenue Bataille-Flandres-Dunkerque, 35042 Rennes, France.
Vernacular Title:
Radioth?rapie guid?e par l'image : pourquoi, comment et r?sultats.
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MeSH Terms
Brain Neoplasms / radiotherapy
Cone-Beam Computed Tomography / methods
Lung Neoplasms / radiotherapy
Neoplasms / radiotherapy*
Otorhinolaryngologic Neoplasms / radiotherapy
Prostatic Neoplasms / radiotherapy
Radiosurgery / instrumentation,  methods
Radiotherapy, Computer-Assisted / instrumentation,  methods*
Radiotherapy, Conformal / instrumentation,  methods
Spinal Neoplasms / radiotherapy

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