Document Detail


Image-based estimation of ventricular fiber orientations for patient-specific simulations.
MedLine Citation:
PMID:  22254646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patient-specific simulation of heart (dys)function aimed at personalizing cardiac therapy are hampered by the absence of in vivo imaging technology for clinically acquiring myocardial fiber orientations. In this research, we develop a methodology to predict ventricular fiber orientations of a patient heart, given the geometry of the heart and an atlas. We test the methodology by comparing the estimated fiber orientations with measured ones, and by quantifying the effect of the estimation error on outcomes of electrophysiological simulations, in normal and failing canine hearts. The new insights obtained from the project will pave the way for the development of patient-specific models of the heart that can aid physicians in personalized diagnosis and decisions regarding electrophysiological interventions.
Authors:
Fijoy Vadakkumpadan; Hermenegild Arevalo; Can Ceritoglu; Michael Miller; Natalia Trayanova
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2011     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-18     Completed Date:  2012-06-12     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1672-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Computer Simulation
Dogs
Heart Conduction System / pathology*,  physiopathology*
Heart Failure / pathology*,  physiopathology*
Heart Ventricles / pathology*,  physiopathology*
Humans
Magnetic Resonance Imaging / methods*
Models, Anatomic
Models, Cardiovascular
Grant Support
ID/Acronym/Agency:
R01 HL091036/HL/NHLBI NIH HHS; R01 HL103428/HL/NHLBI NIH HHS; R01 HL103428-01A1/HL/NHLBI NIH HHS; R01 HL105216/HL/NHLBI NIH HHS; R01-HL082729/HL/NHLBI NIH HHS; R01-HL091036/HL/NHLBI NIH HHS
Comments/Corrections

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