| Iloprost reduces peripheral resistance during femoro-distal reconstruction. | |
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MedLine Citation:
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PMID: 1374040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A randomised placebo-controlled trial was conducted to investigate the effect of iloprost, a stable prostacyclin mimetic, on peripheral resistance during femoro-distal bypass. Patients undergoing femoro-distal long saphenous vein bypass for critical ischaemia received 3000 ng of iloprost or placebo infused into the graft via an unligated side branch over 2 min. Graft blood flow and peripheral resistance were measured for 20 min, using an operative Doppler flowmeter (OpDop 130, SciMed, U.K.) and a pressure transducer to record graft pressure. Postoperatively, graft blood flow was assessed by daily duplex ultrasound for 7 days. Iloprost produced an immediate drop in peripheral resistance in all cases (n = 18) by a mean (range) of 40% (4-80%) compared with controls (n = 15) in whom there was a 5.3% (-8 to +36%) increase in resistance (p less than 0.01, Wilcoxon test). Decreased peripheral resistance in iloprost-treated patients persisted to 20 min. The largest decreases in peripheral resistance occurred in patients with the highest initial resistances (r = 0.56, p less than 0.02). Graft flow during the same period increased by 52% (-7 to 294%) compared with controls in whom there was a 6% (-17 to 26%) increase in flow, (p less than 0.01). Flow remained elevated by 53% over baseline values at 1 week post-infusion in the iloprost-treated group but this did not achieve statistical significance compared to controls in whom flow also increased by 13%. Iloprost produces an immediate decrease in peripheral resistance associated with a prolonged increase in graft blood flow. This may reduce graft failure in the early postoperative period. |
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Authors:
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F C Smith; G M Tsang; H R Watson; C P Shearman |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of vascular surgery Volume: 6 ISSN: 0950-821X ISO Abbreviation: Eur J Vasc Surg Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-06-02 Completed Date: 1992-06-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8709440 Medline TA: Eur J Vasc Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 194-8 Citation Subset: IM |
Affiliation:
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University Department of Vascular Surgery, Queen Elizabeth Hospital, Edgbaston, Birmingham, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anastomosis, Surgical Drug Administration Schedule Female Femoral Artery / surgery* Humans Iloprost / administration & dosage, pharmacology* Intraoperative Period Ischemia / physiopathology, surgery* Leg / blood supply* Male Middle Aged Vascular Resistance / drug effects* |
| Chemical | |
Reg. No./Substance:
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78919-13-8/Iloprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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