| Iloprost in alginate decreases the thrombogenicity of expanded polytetrafluoroethylene. | |
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MedLine Citation:
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PMID: 9144145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vascular prostheses of small diameter perform poorly in vivo, in part because of the high thrombogenicity of available biomaterials. This study examined the thrombogenicity of expanded polytetrafluoroethylene (ePTFE) vascular graft segments (10 mm long x 4 mm i.d.) in vitro before and after impregnation with saline, alginate, or alginate containing the stable prostacyclin analog, iloprost. Each segment was immersed in activated whole blood and the weight of the adherent thrombus was measured at specified intervals. At 6 and 7 min the saline-denucleated group accumulated significantly less thrombus than control (p < .05). Alginate alone was not significantly different from controls. The graft segments treated with alginate + iloprost accumulated significantly less thrombus (p < .05) than all other groups after 6 min. These data demonstrate that denucleation of ePTFE with iloprost in alginate dramatically decreases its in vitro thrombogenicity. |
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Authors:
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P J Viscardi; E A Page; H G Clark; D Serafin; B Klitzman |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of reconstructive microsurgery Volume: 13 ISSN: 0743-684X ISO Abbreviation: J Reconstr Microsurg Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-07-10 Completed Date: 1997-07-10 Revised Date: 2011-02-16 |
Medline Journal Info:
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Nlm Unique ID: 8502670 Medline TA: J Reconstr Microsurg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 303-6 Citation Subset: IM |
Affiliation:
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Plastic Surgery Research Laboratories, Duke University Medical Center, Durham, North Carolina 27710, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alginates* Biocompatible Materials* Blood Vessel Prosthesis Glucuronic Acid Graft Occlusion, Vascular / prevention & control* Hexuronic Acids Humans Iloprost* Platelet Aggregation Inhibitors* Polytetrafluoroethylene* Thrombosis / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Alginates; 0/Biocompatible Materials; 0/Hexuronic Acids; 0/Platelet Aggregation Inhibitors; 576-37-4/Glucuronic Acid; 78919-13-8/Iloprost; 9002-84-0/Polytetrafluoroethylene; 9005-32-7/alginic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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