| Iloprost improves femoro-distal graft flow after a single bolus injection. | |
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MedLine Citation:
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PMID: 1707013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-blind, randomised, placebo-controlled trial was conducted to study the effect of the stable prostacyclin analogue iloprost on femoro-distal graft blood flow. After completing femoro-distal reconstruction, 3000 ng of iloprost or placebo was injected into the graft over 2 min. Graft blood flow, measured by electromagnetic flowmetry, increased by a mean (range) of 94% (12 to 192%) in patients receiving iloprost (n = 15) compared to 6% (-34 to 53%) in controls (n = 16; p less than 0.0001, t-test). Increased graft flow, measured by duplex ultrasound, was maintained in the iloprost group over a 7 day period postoperatively (F = 5.2, p = 0.03; analysis of variance) and remained higher at 7 days (p = 0.007, t-test). Iloprost produces an immediate, sustained increase in graft blood flow after femoro-distal reconstruction and may therefore be of benefit in reducing the incidence of early graft failure. |
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Authors:
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N C Hickey; C P Shearman; M C Crowson; M H Simms; H R Watson |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of vascular surgery Volume: 5 ISSN: 0950-821X ISO Abbreviation: Eur J Vasc Surg Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-05-09 Completed Date: 1991-05-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709440 Medline TA: Eur J Vasc Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 19-22 Citation Subset: IM |
Affiliation:
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Department of Surgery, Selly Oak Hospital, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arteriovenous Shunt, Surgical Blood Flow Velocity / drug effects Double-Blind Method Female Femoral Artery / surgery* Graft Occlusion, Vascular / prevention & control* Humans Iloprost / therapeutic use* Male Regional Blood Flow / drug effects Saphenous Vein / transplantation |
| Chemical | |
Reg. No./Substance:
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78919-13-8/Iloprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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