Document Detail


Iloprost (ZK 36374) prevents angiotensin I conversion in the isolated perfused rat lung against anoxia.
MedLine Citation:
PMID:  2428644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The tissue protective effect of iloprost against anoxia was studied in the isolated perfused rat lung. The change in angiotensin converting enzyme activity was taken as a sign of the biochemical activity of pulmonary vascular endothelium and was measured by bioassay of the vasoconstrictor effects of angiotensin I and angiotensin II. A significant decrease in angiotensin converting enzyme activity was observed in the lungs incubated with Krebs alone and exposed to anoxia for 2 h. The decrease in angiotensin converting enzyme activity following anoxia for 2 and 24 h was prevented by prior pretreatment with iloprost. The pulmonary vasoconstrictor effect of angiotensin II was significantly enhanced following anoxia and iloprost prevented this potentiation. The prevention by iloprost of the decrease in angiotensin converting enzyme activity and increase in the pressor response to angiotensin II was attributed to damage of pulmonary vascular endothelium during anoxia. Possible underlying mechanisms are discussed.
Authors:
H E Aksulu; R K Türker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  128     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-11-17     Completed Date:  1986-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin I / metabolism
Angiotensin-Converting Enzyme Inhibitors*
Animals
Anoxia / drug therapy*,  enzymology
Blood Pressure / drug effects
Epoprostenol / therapeutic use*
Female
Iloprost
Lung / drug effects*,  enzymology
Male
Perfusion
Rats
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 35121-78-9/Epoprostenol; 78919-13-8/Iloprost; 9041-90-1/Angiotensin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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