Document Detail


Iloprost inhalation in mild asthma.
MedLine Citation:
PMID:  23033807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the feasibility of administering iloprost by inhalation in patients with mild atopic asthma.
METHODS: Volunteers underwent supervised inhalation of iloprost in the clinic with measurement of spirometry and blood pressure for 2 hours. The volunteers then inhaled iloprost four times daily at a dose of 2.5 or 5 μg for 14 days. Spirometry, asthma questionnaires, peak flow diaries, measurement of methacholine responsiveness, and exhaled nitric oxide concentrations were obtained prior to and after the treatment period.
RESULTS: Chronic inhalation of iloprost (2.5-5 μg) did not alter spirometry or methacholine responsiveness.
CONCLUSION: Inhaled iloprost in carefully selected volunteers with mild asthma appears to be a suitable intervention to explore the effects of prostacyclin in human asthma.
Authors:
Elizabeth Majeski; Aimee Hoskins; Ryszard Dworski; James R Sheller
Related Documents :
10392327 - Clozapine and metabolite concentrations during treatment of patients with chronic schiz...
17650327 - Low dose quetiapine induced galactorrhoea: a case report.
8688897 - Lack of a strong influence of neuroleptic decanoates on dopaminergic and gabaergic func...
10080557 - Comparative effectiveness of fluphenazine decanoate injections every 2 weeks versus eve...
16377917 - Low-grade inflammation, thrombogenicity, and atherogenic lipid profile in cigarette smo...
18806697 - Pharmacodynamics of mycophenolic acid in cd4+ cells: a single-dose study of impdh and p...
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-04
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  49     ISSN:  1532-4303     ISO Abbreviation:  J Asthma     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-12     Completed Date:  2013-01-02     Revised Date:  2013-01-11    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  England    
Other Details:
Languages:  eng     Pagination:  961-5     Citation Subset:  IM    
Affiliation:
Allergy, Pulmonary and Critical Care Medicine Division, Vanderbilt University School of Medicine, Nashville, TN, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Asthma / drug therapy*
Blood Pressure / drug effects
Bronchial Hyperreactivity
Dose-Response Relationship, Drug
Female
Humans
Iloprost / administration & dosage,  adverse effects,  therapeutic use*
Male
Middle Aged
Nitric Oxide
Prostaglandins I / administration & dosage,  adverse effects,  therapeutic use*
Spirometry
Grant Support
ID/Acronym/Agency:
1 UL1 RR024975/RR/NCRR NIH HHS; KL2 RR024977/RR/NCRR NIH HHS; KL2 TR000446/TR/NCATS NIH HHS; TL1 RR024978/RR/NCRR NIH HHS; TL1 TR000447/TR/NCATS NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 TR000445/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Prostaglandins I; 10102-43-9/Nitric Oxide; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Inhibitory Effect of Chondroitin Sulfate Type E on the Binding Step of Human T-cell Leukemia Virus T...
Next Document:  The impact of hospital-based skilled nursing facility closures on rehospitalizations.