| Iloprost inhalation in mild asthma. | |
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MedLine Citation:
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PMID: 23033807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the feasibility of administering iloprost by inhalation in patients with mild atopic asthma. METHODS: Volunteers underwent supervised inhalation of iloprost in the clinic with measurement of spirometry and blood pressure for 2 hours. The volunteers then inhaled iloprost four times daily at a dose of 2.5 or 5 μg for 14 days. Spirometry, asthma questionnaires, peak flow diaries, measurement of methacholine responsiveness, and exhaled nitric oxide concentrations were obtained prior to and after the treatment period. RESULTS: Chronic inhalation of iloprost (2.5-5 μg) did not alter spirometry or methacholine responsiveness. CONCLUSION: Inhaled iloprost in carefully selected volunteers with mild asthma appears to be a suitable intervention to explore the effects of prostacyclin in human asthma. |
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Authors:
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Elizabeth Majeski; Aimee Hoskins; Ryszard Dworski; James R Sheller |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-10-04 |
Journal Detail:
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Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: 49 ISSN: 1532-4303 ISO Abbreviation: J Asthma Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-12 Completed Date: 2013-01-02 Revised Date: 2013-01-11 |
Medline Journal Info:
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Nlm Unique ID: 8106454 Medline TA: J Asthma Country: England |
Other Details:
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Languages: eng Pagination: 961-5 Citation Subset: IM |
Affiliation:
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Allergy, Pulmonary and Critical Care Medicine Division, Vanderbilt University School of Medicine, Nashville, TN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Asthma / drug therapy* Blood Pressure / drug effects Bronchial Hyperreactivity Dose-Response Relationship, Drug Female Humans Iloprost / administration & dosage, adverse effects, therapeutic use* Male Middle Aged Nitric Oxide Prostaglandins I / administration & dosage, adverse effects, therapeutic use* Spirometry |
| Grant Support | |
ID/Acronym/Agency:
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1 UL1 RR024975/RR/NCRR NIH HHS; KL2 RR024977/RR/NCRR NIH HHS; KL2 TR000446/TR/NCATS NIH HHS; TL1 RR024978/RR/NCRR NIH HHS; TL1 TR000447/TR/NCATS NIH HHS; UL1 RR024975/RR/NCRR NIH HHS; UL1 TR000445/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins I; 10102-43-9/Nitric Oxide; 78919-13-8/Iloprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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