Document Detail

Illness-induced anorexia and its possible function in the caterpillar, Manduca sexta.
MedLine Citation:
PMID:  17126528     Owner:  NLM     Status:  MEDLINE    
Although many animals exhibit illness-induced anorexia when immune-challenged, the adaptive significance of this behavior remains unclear. Injecting Manduca sexta larvae (caterpillars) with live bacteria (Serratia marcescens), heat-killed bacteria or bacterial lipopolysaccharides resulted in a decline in feeding, demonstrating illness-induced anorexia in this species. We used M. sexta to test four commonly suggested adaptive functions for illness-induced anorexia. (1) Food deprivation did not reduce the iron content of the hemolymph. (2) Immune-challenged M. sexta were not more likely to move to a different part of the plant. Therefore, the decline in feeding is unlikely to be an adaptive response allowing the animal to move away from a patch of contaminated food. (3) M. sexta force-fed S. marcescens bacteria were not more susceptible to a S. marcescens systemic infection than were M. sexta force-fed nutrient broth. (4) Force-feeding infected M. sexta during illness-induced anorexia did not increase mortality and short-term food deprivation did not enhance survival. However, force-feeding M. sexta with a high lipid diet (linseed oil and water) resulted in an increase in mortality when challenged with S. marcescens. Force-feeding sucrose or water did not reduce resistance. Force-feeding a high lipid diet into healthy animals did not reduce weight gain, suggesting that it was not toxic. We hypothesize that there is a conflict between lipid metabolism and immune function, although whether this conflict has played a role in the evolution of illness-induced anorexia remains unknown. The adaptive function of illness-induced anorexia requires further study in both vertebrates and invertebrates.
Shelley A Adamo; Tara L Fidler; Catherine A Forestell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-28
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  21     ISSN:  0889-1591     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-09     Completed Date:  2007-04-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  292-300     Citation Subset:  IM    
Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada.
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MeSH Terms
Adaptation, Physiological
Anorexia / etiology*,  immunology
Behavior, Animal / physiology*
Disease Models, Animal
Energy Metabolism
Feeding Behavior / physiology*
Manduca / immunology*,  metabolism,  microbiology
Neuroimmunomodulation / immunology,  physiology
Serratia Infections / complications*,  immunology
Serratia marcescens / immunology*
Comment In:
Brain Behav Immun. 2007 Mar;21(3):290-1   [PMID:  17289469 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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