Document Detail

Ileojejunal transposition delays gastric emptying and decreases fecal water content in dogs with total colectomy.
MedLine Citation:
PMID:  11786773     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of the study was to investigate the effect of ileojejunal transposition, in which the distal ileum is interposed isoperistaltically into the proximal jejunum, on gastric emptying, gastrointestinal motility, and fecal water content in dogs with total colectomy. METHODS: Dogs were divided into three groups: dogs with intact colons (control), total colectomy alone (sham operated group), or total colectomy and ileojejunal transposition group. The alimentary tract was reconstructed by ileal J-pouch-rectal anastomosis. Gastric emptying was measured by a validated freeze-drying method, and gastrointestinal motility was measured by strain gauge force transducers. Plasma peptide YY was measured by specific radioimmunoassay. Fecal water content was measured in dogs with total colectomy. RESULTS: Gastric emptying of solids in the ileojejunal transposition group was delayed longer than 120 minutes after meal ingestion compared with that in the sham operated group. The duration of the digestive state was prolonged in the ileojejunal transposition group, only when compared with the control group. Plasma peptide YY was increased in the ileojejunal transposition group compared with the sham operated group. Fecal water content was decreased in the ileojejunal transposition group compared with the sham operated group. CONCLUSIONS: Ileojejunal transposition delays gastric emptying of solids and decreases fecal water content in dogs with total colectomy, indicating that ileojejunal transposition might be able to improve intractable watery diarrhea after total colectomy.
Tatsuya Ueno; Chikashi Shibata; Hiroo Naito; Xue-Lin Jin; Yuji Funayama; Kouhei Fukushima; Seiki Matsuno; Iwao Sasaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  45     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-11     Completed Date:  2002-02-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-16; discussion 116-8     Citation Subset:  IM    
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
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MeSH Terms
Colectomy / adverse effects*
Colon / physiopathology,  surgery
Diarrhea / etiology*,  physiopathology,  surgery*
Disease Models, Animal
Feces / chemistry*
Gastric Emptying / physiology*
Gastrointestinal Motility / physiology
Ileum / physiopathology,  surgery
Jejunoileal Bypass*
Jejunum / physiopathology,  surgery
Peptide YY / blood
Time Factors
Reg. No./Substance:
106388-42-5/Peptide YY

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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