Document Detail


Ileal resection potentiates 1,2-dimethylhydrazine-induced colonic carcinogenesis.
MedLine Citation:
PMID:  443906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of colonic hyperplasia produced by resection of the distal third of the small bowel (DSBR) on the development of chemical carcinogenesis of the colon by dimethylhydrazine (DMH) was tested in rats. For the most part the amounts of RNA and DNA in the small bowel were the same with the combined treatments as with either one alone; quantities of nucleic acids tended to increase only in transverse and distal colon. After 37 weeks the number of neoplasms per rat was increased six-fold by combining DSBR with DMH. Neoplasms were spread throughout the colon after combined treatment as opposed to the ascending colong after DMH alone. Postresectional hyperplasia appears to increase the incidence and distribution of colon tumors.
Authors:
J E Oscarson; H F Veen; J S Ross; R A Malt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  189     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cocarcinogenesis*
Colon / pathology
Colonic Neoplasms / chemically induced*,  mortality,  pathology
DNA / biosynthesis
Dimethylhydrazines* / administration & dosage
Hyperplasia
Ileum / surgery*
Intestinal Mucosa / pathology
Male
Methylhydrazines* / administration & dosage
Neoplasms, Experimental / chemically induced,  mortality,  pathology
RNA / biosynthesis
Rats
Chemical
Reg. No./Substance:
0/Dimethylhydrazines; 0/Methylhydrazines; 63231-63-0/RNA; 9007-49-2/DNA
Comments/Corrections

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