Document Detail

Ileal dysfunction and bacterial overgrowth in patients with Crohn's disease.
MedLine Citation:
PMID:  6791939     Owner:  NLM     Status:  MEDLINE    
The intestinal bile acid metabolism was studied in sixty-one patients with non-operated Crohn's disease (twenty-seven ileitis and thirty-four ileocolitis patients) by means of the 14C-glycocholate breath test with marker-corrected faecal analysis before and after a short course of antibiotics. The results of the combined breath and faecal analysis were compared with the data of other tests detecting bacterial overgrowth and ileal dysfunction. Fifteen of the sixty-one patients (25%) presented with a 14C excretion pattern consistent with bacterial overgrowth of the small bowel. Repetition of the combined breath and faecal analysis after antibiotic treatment revealed that concurrent ileal dysfunction was present in at least six of these fifteen patients. In twenty other patients elevated marker-corrected 14C faecal excretion indicated ileal dysfunction. Thus, the overall incidence of ileal dysfunction amounted to 26/61 (44%). The sensitivity of the bile acid breath test with marker-corrected stool analysis was comparable to that of aerobic and anaerobic jejunal cultures in twenty non-selected patients for the detection of bacterial overgrowth, and to that of chemical bile acid measurement in stools for the detection of ileal dysfunction. The bile acid breath test with faecal analysis was more sensitive than measurement of glycine-taurine ratio in bile (twenty patients) and the Schilling test.
P Rutgeerts; Y Ghoos; G Vantrappen; H Eyssen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  11     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Bile Acids and Salts / metabolism
Breath Tests
Crohn Disease / diagnosis*,  drug therapy,  microbiology,  physiopathology
Feces / analysis
Glycocholic Acid / diagnostic use
Ileitis / diagnosis,  microbiology
Ileum / physiopathology*
Intestines / microbiology*
Jejunum / microbiology
Middle Aged
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bile Acids and Salts; 475-31-0/Glycocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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