| Ikaros sets thresholds for T cell activation and regulates chromosome propagation. | |
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MedLine Citation:
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PMID: 10204489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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T cell activation involves the sustained accumulation of T cell receptor (TCR) and IL-2 receptor (IL-2R) mediated signaling events that promote cell cycle entry and progression. The Ikaros family of nuclear factors regulate this process by providing thresholds overcome by receptor signaling. T cells with reduced levels of Ikaros activity require fewer TCR engagement events for activation, exhibit a greater proliferative response to IL-2, and are less sensitive to inhibitors of TCR and IL-2R signaling. Upon T cell activation, Ikaros proteins localize in a higher-order chromatin structure where they colocalize with components of the DNA replication machinery. Proliferating T cells with reduced Ikaros activity display chromosome abnormalities. We propose that participation of Ikaros in higher-order chromatin structures controls cell cycle transitions and restricts DNA replication. |
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Authors:
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N Avitahl; S Winandy; C Friedrich; B Jones; Y Ge; K Georgopoulos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Immunity Volume: 10 ISSN: 1074-7613 ISO Abbreviation: Immunity Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-04-23 Completed Date: 1999-04-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9432918 Medline TA: Immunity Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 333-43 Citation Subset: IM |
Affiliation:
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Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / immunology* Cell Cycle Proteins / physiology Cell Division / genetics, immunology Cell Nucleus / metabolism Chromosome Aberrations / immunology Chromosomes / physiology* DNA-Binding Proteins* Ikaros Transcription Factor Interleukin-2 / pharmacology Lymphocyte Activation* / genetics Mice Mice, Inbred C57BL Mice, Inbred Strains Mutation / immunology S Phase / genetics, immunology Signal Transduction / genetics, immunology T-Lymphocytes / cytology, immunology*, metabolism Transcription Factors / genetics, metabolism, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI38342-03/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/DNA-Binding Proteins; 0/Interleukin-2; 0/Transcription Factors; 0/Zfpn1a1 protein, mouse; 148971-36-2/Ikaros Transcription Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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