Document Detail


IkappaBalpha promoter polymorphisms in patients with rheumatoid arthritis.
MedLine Citation:
PMID:  17284228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the role of inhibitor of kappaBalpha promoter polymorphisms in the pathogenesis of rheumatoid arthritis (RA), 140 patients with RA and 115 healthy controls were enrolled in this study. The IkappaBalpha promoter polymorphisms were determined using the polymerase chain reaction/restriction fragment length polymorphisms method. In comparison with IkappaBalpha-826 C/C, the genotype frequency of IkappaBalpha-826 C/T was significantly higher in the patients with RA than that of the controls (P = 0.009, OR = 2.0, 95% CI = 1.2-3.4). The allele frequency of IkappaBalpha-826 T was also significantly increased in patients with RA when compared with that of the controls (P = 0.027, OR = 1.6, 95% CI = 1.1-2.4). In comparison with IkappaBalpha-550 A/A, the genotype frequency of IkappaBalpha-550 A/T was significantly decreased in patients with RA when compared with that of the controls (P = 0.02, OR = 0.2, 95% CI = 0.06-0.8). The allele frequency of IkappaBalpha-550 A was significantly increased in patients with RA (P = 0.007, OR = 5.1, 95% = 1.4-18.2). This study also revealed that the IkappaBalpha-826 T -550 A -519 C haplotype was significantly increased in patients with RA in comparison to that of controls (P = 0.01, OR = 1.8, 95% CI = 1.1-2.8). The IkappaBalpha-826 T and -550 A alleles are associated with susceptibility to RA. Moreover, the IkappaBalpha-826 T -550 A -519 C haplotype is associated with susceptibility to RA in Taiwan.
Authors:
C-H Lin; T-T Ou; C-C Wu; W-C Tsai; H-W Liu; J-H Yen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of immunogenetics     Volume:  34     ISSN:  1744-3121     ISO Abbreviation:  Int. J. Immunogenet.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-05-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101232337     Medline TA:  Int J Immunogenet     Country:  England    
Other Details:
Languages:  eng     Pagination:  51-4     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Arthritis, Rheumatoid / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease*
Haplotypes
Humans
I-kappa B Proteins / genetics*
Male
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Promoter Regions, Genetic / genetics
Chemical
Reg. No./Substance:
0/I-kappa B Proteins; 139874-52-5/NF-kappaB inhibitor alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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