Document Detail


IgM multiple myeloma: disease definition, prognosis, and differentiation from Waldenstrom's macroglobulinemia.
MedLine Citation:
PMID:  20842638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IgM multiple myeloma (MM) and Waldenstrom's macroglobulinemia (WM) are two distinct hematologic entities with the common finding of an IgM monoclonal gammopathy. Distinguishing these two diagnoses is critical as the approach to therapy is different. A priori, we defined IgM MM as a symptomatic clonal plasma cell proliferative disorder characterized by an IgM monoclonal protein (regardless of size), 10% or more plasma cells on bone marrow biopsy, plus the presence of lytic bone lesions and/or translocation t(11;14). Twenty-one patients met this definition of IgM MM. All 21 patients had lytic bone lesions. Of the 16 evaluated with FISH, 6 (38%) demonstrated t(11;14). Median overall survival was 30 months, which is similar to non-IgM myeloma patients treated during this period and shorter than what would be expected for WM. In this, the largest series of patients with IgM MM, we describe the clinical features and prognosis of patient with IgM MM using a strict definition for the disease. The subset of patients without lytic lesions or t(11;14) but with immunophenotypic features suggestive of MM need further study.
Authors:
Steven R Schuster; Sundararajan Vincent Rajkumar; Angela Dispenzieri; William Morice; Alvaro Moreno Aspitia; Stephen Ansell; Robert Kyle; Joseph Mikhael
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  85     ISSN:  1096-8652     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-26     Completed Date:  2010-12-10     Revised Date:  2013-08-22    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  853-5     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley-Liss, Inc.
Affiliation:
Division of Hematology, Mayo Clinic Arizona, Scottsdale, AZ, USA. schuster.steven1@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Bone Diseases
Bone Marrow / pathology
Clone Cells / pathology
Diagnosis, Differential
Humans
Immunoglobulin M*
Middle Aged
Multiple Myeloma / diagnosis*
Prognosis
Survival Rate
Translocation, Genetic
Waldenstrom Macroglobulinemia / diagnosis*
Grant Support
ID/Acronym/Agency:
R01 CA107476/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Immunoglobulin M
Comments/Corrections
Comment In:
Am J Hematol. 2011 Aug;86(8):717; author reply 718-9   [PMID:  21761439 ]
Am J Hematol. 2011 Aug;86(8):717-8; author reply 718-9   [PMID:  21630314 ]

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