Document Detail

Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis.
MedLine Citation:
PMID:  23300096     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: The novel finding of highly abundant IgG4+ BCR clones in blood and tissue of patients with active IAC, which disappear upon corticosteroid treatment, suggests that specific B cell responses are pivotal to the pathogenesis of IAC. (HEPATOLOGY 2013 ).
Lucas J Maillette de Buy Wenniger; Marieke E Doorenspleet; Paul L Klarenbeek; Joanne Verheij; Frank Baas; Ronald P Oude Elferink; Paul P Tak; Niek de Vries; Ulrich Beuers
Related Documents :
23529856 - Co-activation through tlr4 and tlr9 but not tlr2 skews treg-mediated modulation of igs ...
23768926 - Prolonged in vitro expansion partially affects phenotypic features and osteogenic poten...
23700396 - Tumor cell clone expressing the membrane-bound form of il-12p35 subunit stimulates anti...
23922396 - T-box transcription factor t-bet, a key player in a unique type of b-cell activation es...
9829726 - Antagonistic effects of systemic interleukin 2 on immune tcell-mediated graft-versus-le...
21806926 - Shear stress regulates adhesion and rolling of cd44+ leukemic and hematopoietic progeni...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-05-08
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2013-08-16     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2390-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Case-Control Studies
Cholangitis / blood,  immunology*
Duodenum / immunology
Immunoglobulin G / chemistry*
Immunoglobulin Heavy Chains / chemistry
Middle Aged
Prospective Studies
Receptors, Antigen, B-Cell / chemistry*
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin Heavy Chains; 0/Receptors, Antigen, B-Cell
Comment In:
Hepatology. 2013 Jun;57(6):2110-3   [PMID:  23424072 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Social rank and symptom change in eating disorders: a 6-month longitudinal study.
Next Document:  A mathematical model for maximizing the value of phase 3 drug development portfolios incorporating b...