Document Detail

Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis.
MedLine Citation:
PMID:  23300096     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: The novel finding of highly abundant IgG4+ BCR clones in blood and tissue of patients with active IAC, which disappear upon corticosteroid treatment, suggests that specific B cell responses are pivotal to the pathogenesis of IAC. (HEPATOLOGY 2013 ).
Lucas J Maillette de Buy Wenniger; Marieke E Doorenspleet; Paul L Klarenbeek; Joanne Verheij; Frank Baas; Ronald P Oude Elferink; Paul P Tak; Niek de Vries; Ulrich Beuers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-05-08
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2013-08-16     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2390-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Case-Control Studies
Cholangitis / blood,  immunology*
Duodenum / immunology
Immunoglobulin G / chemistry*
Immunoglobulin Heavy Chains / chemistry
Middle Aged
Prospective Studies
Receptors, Antigen, B-Cell / chemistry*
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin Heavy Chains; 0/Receptors, Antigen, B-Cell
Comment In:
Hepatology. 2013 Jun;57(6):2110-3   [PMID:  23424072 ]

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