Document Detail

IgG2 immunodeficiency: association to pediatric patients with bacterial meningoencephalitis.
MedLine Citation:
PMID:  10770879     Owner:  NLM     Status:  MEDLINE    
An IgG subclass deficiency is often associated with bacterial infections. We studied four pediatric patients suffering from meningoencephalitis, two of them due to Streptococcus pneumoniae and two due to Haemophilus influenzae type b. Simultaneous diagnostic serum and cerebrospinal fluid samples were taken during income. The four subclasses of IgG and albumin were quantified in both biologic fluids by radial immunodiffusion. Very low levels of seric IgG2 with non detectable cerebrospinal fluid IgG2 were found in the patients. No intrathecal IgG subclass synthesis was found in two patients. One patient with S. pneumoniae had IgG3 intrathecal synthesis. Intrathecal IgG1, IgG3 and IgG4 synthesis was found in one patient suffering from H. influenzae according with reibergrams. Substitutive therapy with intravenous gammaglobulin was given to the patients as part of the treatment.
X Escobar-Pérez; A J Dorta-Contreras; M T Interián-Morales; E Noris-García; M Ferrá-Valdés
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  58     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-08-16     Completed Date:  2000-08-16     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Laboratorio de Inmunología, Hospital Psiquiátrico San Miguel del Padrón, Ciudad Habana, Cuba.
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MeSH Terms
Albumins / cerebrospinal fluid
Bacterial Infections / drug therapy,  immunology*
Child, Preschool
IgG Deficiency / immunology*
Immunoglobulin G / blood,  cerebrospinal fluid
Infant, Newborn
Meningoencephalitis / drug therapy,  immunology*
Serum Albumin / analysis
gamma-Globulins / therapeutic use
Reg. No./Substance:
0/Albumins; 0/Immunoglobulin G; 0/Serum Albumin; 0/gamma-Globulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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