| The IgG and transferrin receptors of the human syncytiotrophoblast microvillus plasma membrane. | |
| | |
MedLine Citation:
|
PMID: 6278968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fc gamma receptor activity has been demonstrated using a radioisotopic assay on human syncytiotrophoblast microvillus plasma membrane (StMPM) vesicle preparations isolated from normal full-term placentas. Prior chaotropic extraction to remove extrinsic membrane protein from StMPM preparations was shown to increase radiolabeled IgG uptake by up to 30%. Polyacrylamide disc gel electrophoresis (PAGE) has been used to indicate that the StMPM receptor for transferrin solubilizes in 1% sodium deoxycholate and retains its binding activity for transferrin. Quantitative data for both Fc gamma and transferrin receptors obtained following study of isolated StMPM preparations are summarized. Current concepts for the potential role of trophoblast Fc gamma and transferrin receptors in the mechanisms of transplacental passage of IgG and iron, respectively, from mother to fetus are illustrated and discussed. |
| | |
Authors:
|
P M Johnson; P J Brown |
Related Documents
:
|
16137788 - Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental ... 9633518 - Oxidative stress leads to a rapid alteration of transferrin receptor intravesicular tra... 3005248 - Expression and phosphorylation of transferrin receptors in mitogen-activated peripheral... 8063758 - Receptor-mediated nuclear translocation of growth hormone. 22189138 - Synthesis of novel histamine h4 receptor antagonists. 11960628 - Characterization of membrane nongenomic receptors for progesterone in human spermatozoa. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction Volume: 1 ISSN: 0271-7352 ISO Abbreviation: Am J Reprod Immunol Publication Date: 1980 |
Date Detail:
|
Created Date: 1982-05-12 Completed Date: 1982-05-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8111069 Medline TA: Am J Reprod Immunol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 4-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Transport, Active Cell Membrane / immunology, metabolism Female Humans Immunoglobulin G / metabolism* Immunoglobulin gamma-Chains Iron / metabolism Maternal-Fetal Exchange Pregnancy Receptors, Cell Surface / metabolism* Receptors, Fc / metabolism* Receptors, Transferrin Trophoblasts / immunology, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin G; 0/Immunoglobulin gamma-Chains; 0/Receptors, Cell Surface; 0/Receptors, Fc; 0/Receptors, Transferrin; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Histocompatibility antigens in pregnancy, abortions, infertility, preeclampsia, and trophoblast neop...
Next Document: Cell-mediated immunity to cytomegalovirus in pregnant women.