Document Detail

IgG antibodies against microorganisms and atopic disease in Danish adults: the Copenhagen Allergy Study.
MedLine Citation:
PMID:  12704368     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Seropositivity to food-borne and orofecal microorganisms (hepatitis A virus, Helicobacter pylori, and Toxoplasma gondii ), which are considered to be markers of poor hygiene, has been reported to be associated with a lower prevalence of atopy. In contrast, colonization of the gut with Clostridium difficile, a potential intestinal bacterial pathogen, in early childhood may be associated with a higher prevalence of atopy. OBJECTIVE: The objective of this study was to investigate the association between atopy and exposure to 2 groups of food-borne and orofecal microorganisms: (1) markers of a poor hygiene and (2) intestinal bacterial pathogens. METHODS: A cross-sectional population-based study of 15- to 69-year-olds living in Copenhagen, Denmark, was carried out in 1990 to 1991. Atopy was defined as a positive test result for specific IgE to at least 1 of 6 inhalant allergens. Exposure to microorganisms was assessed as IgG seropositivity to microorganisms. RESULTS: Seropositivity to 2 or 3 markers of poor hygiene (hepatitis A virus, H pylori, and T gondii ) was associated with a lower prevalence of atopy (adjusted odds ratio, 0.5; 95% CI, 0.3 to 0.8). In contrast, seropositivity to 2 or 3 intestinal bacterial pathogens (C difficile, Campylobacter jejuni, and Yersinia enterocolitica ) was associated with a higher prevalence of atopy (adjusted odds ratio, 1.7; 95% CI, 1.2 to 2.6). CONCLUSION: Exposure to markers of poor hygiene was associated with a lower prevalence of atopy, whereas exposure to intestinal bacterial pathogens was associated with a higher prevalence of atopy. These findings raise the hypothesis that different groups of food-borne and orofecal microorganisms may have different effects on the risk of atopy.
Allan Linneberg; Christian Ostergaard; Michael Tvede; Leif Pervical Andersen; Niels Henrik Nielsen; Flemming Madsen; Lars Frølund; Asger Dirksen; Torben Jørgensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  111     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-21     Completed Date:  2003-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  847-53     Citation Subset:  AIM; IM    
Centre for Preventive Medicine, Glostrup University Hospital, Denmark.
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MeSH Terms
Antibodies, Bacterial / blood
Antibodies, Protozoan / blood
Cross-Sectional Studies
Helicobacter pylori / immunology
Hepatitis A Antibodies / blood
Hypersensitivity / etiology*
Immunoglobulin G / blood*
Middle Aged
Toxoplasma / immunology
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Antibodies, Protozoan; 0/Hepatitis A Antibodies; 0/Immunoglobulin G

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