Document Detail


IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance.
MedLine Citation:
PMID:  12209091     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Individuals with pollen allergy often have IgE against plant-derived foods. This can be due to cross-reactive IgE against Bet v 1 and homologues, profilins, and/or cross-reactive carbohydrate determinants.
OBJECTIVE: The aim of this study was to correlate sensitization to Bet v 1 and profilin with individual recognition patterns to plant foods and clinical relevance.
METHODS: Fifty-two patients with pollen allergy and IgE against at least one plant-derived food were included in the study. Adverse reactions to plant-derived foods were documented by using standardized interviews. Skin prick tests were performed for pollen (grass, birch, and mugwort) and 14 plant-derived foods. In addition, recombinant (r) Bet v 1 and rBet v 2 (profilin) were tested intracutaneously. Specific IgE against the abovementioned allergens were determined by means of RAST. Cross-reactivity was studied by means of RAST inhibition.
RESULTS: Eighty-five percent of patients were sensitized to Bet v 1, and 71% were sensitized to profilin. Profilin was associated with a higher number of positive RAST results to plant-derived foods than Bet v 1. In contrast, Bet v 1 was associated with more positive skin prick test responses and more food-related symptoms. Sensitization to Bet v 1 was associated with IgE against apple, hazelnut, and peach, whereas sensitization to profilin was associated with positive RAST results to all investigated plant-derived foods except apple, peach, and melon.
CONCLUSIONS: IgE antibodies against Bet v 1 have a more limited spectrum of cross-reactivity than those against profilin, but they frequently give rise to clinically relevant cross-reactivities to food. In analogy to anticarbohydrate IgE, cross-reactive IgE against food profilins have no or very limited clinical relevance.
Authors:
Marjolein Wensing; Jaap H Akkerdaas; W Astrid van Leeuwen; Steven O Stapel; Carla A F M Bruijnzeel-Koomen; Rob C Aalberse; Bert J E G Bast; André C Knulst; Ronald van Ree
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  110     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-04     Completed Date:  2002-10-07     Revised Date:  2011-06-21    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  435-42     Citation Subset:  AIM; IM    
Affiliation:
Department of Dermatology/Allergology, University Medical Centre Utrecht, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Allergens / immunology
Antigens, Plant
Contractile Proteins*
Cross Reactions
Female
Food Hypersensitivity / diagnosis,  immunology
Humans
Hypersensitivity, Immediate / classification,  diagnosis*,  immunology*
Immunoglobulin E / blood,  immunology*
Male
Microfilament Proteins / immunology*
Middle Aged
Plant Proteins / immunology*
Profilins
Radioallergosorbent Test
Rhinitis, Allergic, Seasonal / diagnosis,  immunology
Chemical
Reg. No./Substance:
0/Allergens; 0/Antigens, Plant; 0/Contractile Proteins; 0/Microfilament Proteins; 0/Plant Proteins; 0/Profilins; 126161-14-6/Bet v 1 allergen, Betula; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The IL1A genotype associates with atopy in nonasthmatic adults.
Next Document:  CD40 engagement enhances eosinophil survival through induction of cellular inhibitor of apoptosis pr...