| IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance. | |
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MedLine Citation:
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PMID: 12209091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Individuals with pollen allergy often have IgE against plant-derived foods. This can be due to cross-reactive IgE against Bet v 1 and homologues, profilins, and/or cross-reactive carbohydrate determinants. OBJECTIVE: The aim of this study was to correlate sensitization to Bet v 1 and profilin with individual recognition patterns to plant foods and clinical relevance. METHODS: Fifty-two patients with pollen allergy and IgE against at least one plant-derived food were included in the study. Adverse reactions to plant-derived foods were documented by using standardized interviews. Skin prick tests were performed for pollen (grass, birch, and mugwort) and 14 plant-derived foods. In addition, recombinant (r) Bet v 1 and rBet v 2 (profilin) were tested intracutaneously. Specific IgE against the abovementioned allergens were determined by means of RAST. Cross-reactivity was studied by means of RAST inhibition. RESULTS: Eighty-five percent of patients were sensitized to Bet v 1, and 71% were sensitized to profilin. Profilin was associated with a higher number of positive RAST results to plant-derived foods than Bet v 1. In contrast, Bet v 1 was associated with more positive skin prick test responses and more food-related symptoms. Sensitization to Bet v 1 was associated with IgE against apple, hazelnut, and peach, whereas sensitization to profilin was associated with positive RAST results to all investigated plant-derived foods except apple, peach, and melon. CONCLUSIONS: IgE antibodies against Bet v 1 have a more limited spectrum of cross-reactivity than those against profilin, but they frequently give rise to clinically relevant cross-reactivities to food. In analogy to anticarbohydrate IgE, cross-reactive IgE against food profilins have no or very limited clinical relevance. |
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Authors:
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Marjolein Wensing; Jaap H Akkerdaas; W Astrid van Leeuwen; Steven O Stapel; Carla A F M Bruijnzeel-Koomen; Rob C Aalberse; Bert J E G Bast; André C Knulst; Ronald van Ree |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 110 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-04 Completed Date: 2002-10-07 Revised Date: 2011-06-21 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 435-42 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology/Allergology, University Medical Centre Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Allergens / immunology Antigens, Plant Contractile Proteins* Cross Reactions Female Food Hypersensitivity / diagnosis, immunology Humans Hypersensitivity, Immediate / classification, diagnosis*, immunology* Immunoglobulin E / blood, immunology* Male Microfilament Proteins / immunology* Middle Aged Plant Proteins / immunology* Profilins Radioallergosorbent Test Rhinitis, Allergic, Seasonal / diagnosis, immunology |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Antigens, Plant; 0/Contractile Proteins; 0/Microfilament Proteins; 0/Plant Proteins; 0/Profilins; 126161-14-6/Bet v 1 allergen, Betula; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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