| IgE-mediated occupational asthma from epoxy resin. | |
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MedLine Citation:
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PMID: 18716402 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Epoxy resins (ERs) are used in paints and other protective coatings, including flooring materials. Bisphenol A diglycidyl ether (BADGE) ERs (BADGE ERs) account for about 75% of the ERs used world-wide. ERs can cause both immediate and delayed allergic reactions, but immediate reactions are rare. METHODS: Occupational asthma (OA) was diagnosed on the basis of a specific challenge test combined with the patient's history of occupational exposure and respiratory symptoms. RESULTS: A 39-year-old nonsmoking construction worker experienced dyspnea when laying ER-containing floors, but not in other situations. He also presented skin symptoms. IgE-mediated allergy to BADGE ER could be verified with both serum IgE antibodies and skin prick tests. The specific bronchial challenge test with BADGE ER caused an immediate asthmatic reaction. On patch testing, a positive reaction was provoked by BADGE ER. CONCLUSIONS: This is the first study on a patient exposed to BADGE ER with IgE-mediated immediate OA, based on a positive inhalation challenge test. If work-related respiratory symptoms develop when handling ERs, the possibility of OA should be recognized. |
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Authors:
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Timo Hannu; Heikki Frilander; Paula Kauppi; Outi Kuuliala; Kristiina Alanko |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-21 |
Journal Detail:
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Title: International archives of allergy and immunology Volume: 148 ISSN: 1423-0097 ISO Abbreviation: Int. Arch. Allergy Immunol. Publication Date: 2009 |
Date Detail:
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Created Date: 2008-12-17 Completed Date: 2009-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211652 Medline TA: Int Arch Allergy Immunol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 41-4 Citation Subset: IM |
Copyright Information:
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(c) 2008 S. Karger AG, Basel. |
Affiliation:
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Occupational Medicine Team, Finnish Institute of Occupational Health, Helsinki, Finland. timo.hannu@ttl.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / diagnosis, immunology* Bronchial Provocation Tests Epoxy Compounds / immunology* Epoxy Resins* Humans Immunoglobulin E / blood*, immunology Male Occupational Diseases / diagnosis, immunology* Skin Tests Spirometry |
| Chemical | |
Reg. No./Substance:
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0/Epoxy Compounds; 0/Epoxy Resins; 1675-54-3/2,2-bis(4-glycidyloxyphenyl)propane; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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