Document Detail

IgE-mediated occupational asthma from epoxy resin.
MedLine Citation:
PMID:  18716402     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Epoxy resins (ERs) are used in paints and other protective coatings, including flooring materials. Bisphenol A diglycidyl ether (BADGE) ERs (BADGE ERs) account for about 75% of the ERs used world-wide. ERs can cause both immediate and delayed allergic reactions, but immediate reactions are rare. METHODS: Occupational asthma (OA) was diagnosed on the basis of a specific challenge test combined with the patient's history of occupational exposure and respiratory symptoms. RESULTS: A 39-year-old nonsmoking construction worker experienced dyspnea when laying ER-containing floors, but not in other situations. He also presented skin symptoms. IgE-mediated allergy to BADGE ER could be verified with both serum IgE antibodies and skin prick tests. The specific bronchial challenge test with BADGE ER caused an immediate asthmatic reaction. On patch testing, a positive reaction was provoked by BADGE ER. CONCLUSIONS: This is the first study on a patient exposed to BADGE ER with IgE-mediated immediate OA, based on a positive inhalation challenge test. If work-related respiratory symptoms develop when handling ERs, the possibility of OA should be recognized.
Timo Hannu; Heikki Frilander; Paula Kauppi; Outi Kuuliala; Kristiina Alanko
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-21
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  148     ISSN:  1423-0097     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2009  
Date Detail:
Created Date:  2008-12-17     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  41-4     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Occupational Medicine Team, Finnish Institute of Occupational Health, Helsinki, Finland.
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MeSH Terms
Asthma / diagnosis,  immunology*
Bronchial Provocation Tests
Epoxy Compounds / immunology*
Epoxy Resins*
Immunoglobulin E / blood*,  immunology
Occupational Diseases / diagnosis,  immunology*
Skin Tests
Reg. No./Substance:
0/Epoxy Compounds; 0/Epoxy Resins; 1675-54-3/2,2-bis(4-glycidyloxyphenyl)propane; 37341-29-0/Immunoglobulin E

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