Document Detail

IgE-mediated allergy to local anaesthetics: separating fact from perception: a UK perspective.
MedLine Citation:
PMID:  22593127     Owner:  NLM     Status:  MEDLINE    
Local anaesthetic (LA) agents have been routinely used in dentistry, ophthalmology, minor surgery, and obstetrics since the late nineteenth century. Reports relating to adverse reactions and LA allergy have appeared in the published literature for several years. However, the incidence of true, IgE-mediated LA allergy remains uncertain and is presumed to be very low. We critically reviewed the English language literature on suspected LA allergy and its investigation with the aim of estimating the reported prevalence and analysing the role of different tests currently used to identify and confirm LA allergy. Twenty-three case series involving 2978 patients were identified and analysed. Twenty-nine of these patients had true IgE-mediated allergy to LA, thus confirming the reported prevalence of LA allergy in large series to be <1% (0.97%). The protocols used in the investigation of these patients have also been discussed. Evidence from this review confirms the rarity of IgE-mediated allergy to LA and supports an investigation strategy based on using the clinical history to select patients for skin testing and challenge. We believe that such a triage process would alleviate pressures on allergy services without compromising patient safety.
M V Bhole; A L Manson; S L Seneviratne; S A Misbah
Related Documents :
7352087 - Gastrointestinal complications of modern intrauterine devices.
17116627 - Subcutaneous emphysema and pneumomediastinum secondary to dental extraction: a case rep...
23114877 - Clinicopathological review of pallidonigroluysian atrophy.
9124667 - Delayed upper airway obstruction. a life-threatening complication of dettol poisoning.
18263837 - Cephalopagus conjoined twins in a leopard cat (prionailurus bengalensis).
22350577 - Jejunal vasculitis in patient with rheumatoid arthritis: case report and literature rev...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  108     ISSN:  1471-6771     ISO Abbreviation:  Br J Anaesth     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-17     Completed Date:  2012-07-23     Revised Date:  2012-11-08    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  903-11     Citation Subset:  IM    
Department of Immunology, Oxford University Hospitals NHS Trust, Academic Street, Level 4, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthetics, Local / adverse effects*,  immunology
Cross Reactions
Drug Hypersensitivity / diagnosis,  etiology*
Great Britain
Immunoglobulin E / immunology*
Skin Tests
Reg. No./Substance:
0/Anesthetics, Local; 37341-29-0/Immunoglobulin E
Erratum In:
Br J Anaesth. 2012 Oct;109(4):669

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Supplemental intravenous crystalloids for the prevention of postoperative nausea and vomiting: quant...
Next Document:  Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcom...