Document Detail

IgE isotype determination: epsilon-germline gene transcription, DNA recombination and B-cell differentiation.
MedLine Citation:
PMID:  11359628     Owner:  NLM     Status:  MEDLINE    
Immunoglobulin class switching is the process which determines whether a B-cell secretes antibodies of the IgM, IgG, IgA or IgE class (or isotype). IgE is the antibody that mediates the allergic response by sensitising mast cells to allergens at the mucosal barrier. Class switching proceeds by three successive steps, culminating in the synthesis and secretion of antibody: these are germline gene transcription, DNA recombination and B-cell differentiation. We review here the present state of knowledge concerning the mechanisms involved in each of these steps, with particular reference to IgE. Intervention in the mechanisms that specify the selection of IgE may offer a means to combat allergy.
H J Gould; R L Beavil; D Vercelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  British medical bulletin     Volume:  56     ISSN:  0007-1420     ISO Abbreviation:  Br. Med. Bull.     Publication Date:  2000  
Date Detail:
Created Date:  2001-05-25     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376542     Medline TA:  Br Med Bull     Country:  England    
Other Details:
Languages:  eng     Pagination:  908-24     Citation Subset:  IM    
Randall Centre for Molecular Mechanisms of Cell Function, King's College London, Guy's Campus, London SE1 1UL, UK.
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MeSH Terms
Antibodies / immunology*
B-Lymphocytes / immunology
Cell Differentiation
Hypersensitivity / genetics,  immunology*
Immunoglobulin Class Switching*
Immunoglobulin E / immunology*
Immunoglobulin Isotypes / analysis*
Immunoglobulin epsilon-Chains / genetics*
Recombination, Genetic
T-Lymphocytes, Helper-Inducer / immunology
Transcription, Genetic
Reg. No./Substance:
0/Antibodies; 0/Immunoglobulin Isotypes; 0/Immunoglobulin epsilon-Chains; 37341-29-0/Immunoglobulin E

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