Document Detail


IgE-containing circulating immune complexes in Churg-Strauss vasculitis.
MedLine Citation:
PMID:  3890149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In five patients with vasculitis, hypereosinophilia, and elevated serum IgE levels a diagnosis of Churg-Strauss syndrome was established. To identify a possible role of IgE in pathogenic mechanisms leading to the vasculitis, we performed a sequential precipitation of the patients' sera with different concentrations of polyethylene glycol (PEG) 6000. Using a radio immunosorbent test, we tested the precipitates obtained for IgE. Considerable amounts of IgE were traced in the serum precipitates of all patients, especially after the second precipitation step (4.0% PEG). In contrast, no IgE-containing precipitates were detectable in sera from patients with different allergic diseases and high IgE serum levels. Together with an increase in C3d serum levels and the failure to demonstrate C1q-binding material in patients' sera, these data suggest the involvement of IgE-containing immune complexes in the pathogenesis of Churg-Strauss vasculitis, activating the complement via the alternate pathway.
Authors:
B J Manger; F E Krapf; M Gramatzki; H G Nüsslein; G R Burmester; P B Krauledat; J R Kalden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  21     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-07-02     Completed Date:  1985-07-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  369-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antigen-Antibody Complex / analysis*
Chemical Precipitation
Chromatography, Gel
Complement C3 / analysis
Fluorescent Antibody Technique
Humans
Immunoglobulin E / analysis*
Muscle, Smooth, Vascular / immunology
Plasmapheresis
Polyethylene Glycols / pharmacology
Steroids / therapeutic use
Vasculitis, Leukocytoclastic, Cutaneous / immunology*,  therapy
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Complement C3; 0/Polyethylene Glycols; 0/Steroids; 37341-29-0/Immunoglobulin E

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