Document Detail


IgE, allergic diseases, and omalizumab.
MedLine Citation:
PMID:  17073688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunoglobulin E (IgE) plays a central role in the development of allergic diseases. In sensitized individuals, IgE antibodies bind to receptors on mast cell and basophil surfaces, releasing preformed and newly generated mediators that initiate an immunologic cascade and inflammatory symptoms. Omalizumab (Xolair) is a humanized monoclonal antibody designed to bind specifically to IgE. It was approved by the United States Food and Drug Administration in 2003 for the treatment of patients with moderate-to-severe persistent asthma that is inadequately controlled with inhaled corticosteroids (ICS) and who have a positive skin test or in vitro reactivity to a perennial aeroallergen. In clinical trials in such patients, omalizumab reduced the incidence of asthma exacerbations, severe exacerbations, the use of rescue medication, and improved both symptoms and quality of life (QOL).
Authors:
L M DuBuske
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  12     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-31     Completed Date:  2007-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3929-44     Citation Subset:  IM    
Affiliation:
Consultant in Allergy, Brigham and Women's Hospital, Boston, MA, USA. Ldubuske@aol.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / metabolism*,  therapeutic use
Binding Sites, Antibody*
Humans
Hypersensitivity / immunology*,  metabolism,  therapy*
Immunoglobulin E / metabolism*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Binding Sites, Antibody; 0/omalizumab; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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