| IgE and IgG(4) autoantibodies against DFS70/LEDGF in atopic dermatitis. | |
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MedLine Citation:
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PMID: 21329475 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background. DFS70/LEDGF is a known survival factor, growth factor, and HIV-1 transporter. It is also an autoantigen recognized by IgG autoantibodies (aAbs) in patients with atopic dermatitis (AD). In the past few decades, various IgE aAbs against self-proteins have been identified in AD. Although DFS70 is considered to be one of these proteins, to date, there has not been a detailed analysis of the significance of this putative autoantigen. Objective and methods. Using recombinant protein that was generated using a baculovirus and insect cell system, we established an ELISA that can measure IgE-anti-DFS70 aAbs and IgG(4)-anti-DFS70 aAbs. Sera obtained from 61 AD patients and 20 healthy donors were analyzed using the ELISA. Results. Nine of 61 AD patients were determined to be IgE-anti-DFS70 aAb-positive. IgG(4)-anti-DFS70 aAbs were detected in nine of 61 patients. The serum thymus and activation-regulated chemokine concentrations were significantly higher in the group that was positive for both aAbs compared to the aAb-negative group, although the total serum IgE levels were not significantly different between these groups. Conclusion. We conclude that serum IgE-anti-DFS70 aAbs and IgG(4)-anti-DFS70 aAbs may be related to the severity of AD. |
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Authors:
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Kanako Watanabe; Yoshinao Muro; Kazumitsu Sugiura; Yasushi Tomita |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-18 |
Journal Detail:
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Title: Autoimmunity Volume: - ISSN: 1607-842X ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900070 Medline TA: Autoimmunity Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Connective Tissue and Autoimmunity, Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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