| IgA2 allotypes determined by restriction fragment length polymorphism in IgA deficiency. Re-expression of the silent A2m(2) allotype in the children of IgA-deficient patients. | |
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MedLine Citation:
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PMID: 2900854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IgA2 allotyping was performed on DNA from 60 IgA-deficient Caucasian individuals. The frequency of A2m(2) was not statistically different from that of normal controls. Two informative families were selected for further studies. In both families, the A2m(2) allotype (derived from the IgA-deficient parent) was inherited by some of the children, as determined by Southern blotting experiments. In all cases the 'silent' IgA2m2 gene was re-expressed, as judged by conventional serological allotyping of serum proteins. These data strongly argue against structural gene deletions or mutations as a cause of IgA deficiency. |
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Authors:
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L Hammarström; G G de Lange; C I Smith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of immunogenetics Volume: 14 ISSN: 0305-1811 ISO Abbreviation: J. Immunogenet. Publication Date: 1987 Aug-Oct |
Date Detail:
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Created Date: 1988-09-29 Completed Date: 1988-09-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425125 Medline TA: J Immunogenet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 197-201 Citation Subset: IM |
Affiliation:
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Department of Clinical Immunology, Karolinska Institute, Huddinge Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Dysgammaglobulinemia / genetics* Female Gene Frequency Haplotypes Humans IgA Deficiency* Immunoglobulin A / genetics* Immunoglobulin Allotypes / genetics* Immunologic Techniques Male Polymorphism, Restriction Fragment Length |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulin Allotypes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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