Document Detail

IgA pemphigus: a case report and its characteristic clinical features compared with subcorneal pustular dermatosis.
MedLine Citation:
PMID:  10954673     Owner:  NLM     Status:  MEDLINE    
We report a case of IgA pemphigus. A 35-year-old woman had vesiculopustular eruptions on her scalp, trunk, and extremities. Histologic examination showed a subcorneal pustule containing numerous neutrophils without acantholysis. Direct immunofluorescence revealed IgA deposits in the intercellular space throughout the epidermis, more intense in superficial layers and less intense in lower layers. The titer of circulating IgA antibodies was 1:160 in normal human skin as a substrate. Skin lesions responded to dapsone. The IgA autoantibody from this patient did not react with desmogleins or desmocollins when immunoblotting, enzyme-linked immunosorbent assay, or complement DNA transfection was used. We consider the characteristic clinical features that favor the diagnosis of IgA pemphigus rather than classic subcorneal pustular dermatosis as follows: (1) the lesions involve the scalp and/or face, and (2) the distribution of the lesions is more widespread.
Y Niimi; S Kawana; T Kusunoki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  43     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-09-21     Completed Date:  2000-09-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  546-9     Citation Subset:  IM    
Department of Dermatology, Nippon Medical School, and Kusunoki Dermatology Clinic, Tokyo, Japan.
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MeSH Terms
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Face / pathology
Immunoglobulin A / analysis*,  immunology
Pemphigus / diagnosis,  immunology*,  pathology
Scalp / pathology
Skin Diseases, Vesiculobullous / diagnosis*,  pathology
Reg. No./Substance:
0/Immunoglobulin A

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