| IgA nephropathy in two patients with Sj?gren's syndrome: one with concomitant autoimmune hepatitis. | |
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MedLine Citation:
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PMID: 20045999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Concurrent glomeruli and liver involvement in patients with Sj?gren's syndrome (SS) has seldom been reported. Meanwhile, IgA nephropathy (IgAN) associated with SS is not as common as other types of glomerulonephritis, such as membranoproliferative glomerulonephritis (MPGN) and membranous nephropathy (MN). Two patients with SS and IgAN are presented. Case 1 was diagnosed as SS complicated with IgAN (Haas subclass III) and severe AIH, while case 2 was diagnosed as SS and IgAN (Haas subclass I) with serious tubulointerstitial lesions. The true prevalence of IgAN secondary to SS is certainly underestimated and the crucial pathogenetic factors may be polyclonal hypergammaglobulinemia and hypocomplementemia (especially C4). The frequent presence of multiple immunoglobulin and complement deposition in glomeruli, especially weak deposits of C4 and (or) C1q, is an immunofluorescence staining feature of IgAN secondary to SS and may be associated with disease severity and activity. |
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Authors:
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Yizhi Chen; Xuezhi Zhao; Dan Tang; Chenggang Xu; Linlin Sun; Lijun Sun; Jun Wu; Changlin Mei |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-01-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-04 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 37-43 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Shanghai Kidney Disease Quality Control Center, Kidney Institute of Chinese People's Liberation Army, Changzheng Hospital, Second Military Medical University, Shanghai, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antirheumatic Agents / therapeutic use Female Glomerulonephritis, IGA / complications*, drug therapy, pathology Hepatitis, Autoimmune / complications* Humans Kidney Glomerulus / pathology Middle Aged Salivary Glands / pathology Sjogren's Syndrome / complications*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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