| IgA multiple myeloma presenting as Henoch-Schönlein purpura/polyarteritis nodosa overlap syndrome. | |
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MedLine Citation:
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PMID: 8630124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the unusual case of a man with a 5-year history of relapsing Henoch-Schonlein purpura (HSP) and macroscopic polyarteritis nodosa (PAN) as early manifestations of IgA kappa multiple myeloma. The glomeruli contained monoclonal IgA kappa deposits, without other immunoglobulins or lambda light chains. Glomerular deposits lacked the usual electron density but could be demonstrated by immunoelectron microscopy. Multisystem large vessel vasculitis (antineutrophil cytoplasmic antibody negative) produced aneurysms of renal and hepatic arteries, whereas small vessel vasculitis affected the skin and glomeruli, producing a symptom complex of HSP with dermal and glomerular deposits of IgA. We conclude that HSP/overlap syndrome may be the initial manifestation of IgA myeloma and should be considered within the spectrum of monoclonal IgA deposition disease. |
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Authors:
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D Birchmore; C Sweeney; D Choudhury; M F Konwinski; K Carnevale; V D'Agati |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 39 ISSN: 0004-3591 ISO Abbreviation: Arthritis Rheum. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-06-25 Completed Date: 1996-06-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 698-703 Citation Subset: AIM; IM |
Affiliation:
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Department of Veterans Affairs Medical and Regional Office Center, Wilmington, Delaware 19805 USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Immunoglobulin A* Male Microscopy, Immunoelectron Middle Aged Multiple Myeloma / complications* Paraproteinemias / complications*, pathology Polyarteritis Nodosa / etiology* Purpura, Schoenlein-Henoch / etiology*, pathology Syndrome |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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