Document Detail


IgA in dermatitis-herpetiformis skin is dimeric.
MedLine Citation:
PMID:  6121142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Skin-biopsy specimens from six patients with dermatitis herpetiformis (DH) were examined by means of indirect immunofluorescence with specific rabbit antisera for the presence of in-vivo J chain and secretory component in IgA deposits. The ability of IgA to bind purified secretory component was studied by means of indirect immunofluorescence with antisera to secretory component. Positive J-chain staining associated with IgA deposits was seen in cryostat sections of all seven DH skin-biopsy specimens. In-vivo secretory component was not detected, but on treatment of sections with a solution of purified secretory component, binding of the latter in the region of the IgA deposits was demonstrated in six of the seven DH skin-biopsy specimens. With double fluorochrome staining binding of secretory component was shown to be essentially coextensive with the IgA deposits. These findings suggest that the IgA deposited in DH skin originates from plasma cells in the small intestine.
Authors:
D J Unsworth; A W Payne; J N Leonard; L Fry; E J Holborow
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  478-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Binding Sites, Antibody
Biopsy
Dermatitis Herpetiformis / immunology*
Humans
Immunoglobulin A / analysis*
Immunoglobulin J-Chains / analysis*
Intestine, Small / immunology
Pemphigoid, Bullous / immunology
Secretory Component / analysis
Skin / immunology*,  pathology
Chemical
Reg. No./Substance:
0/Binding Sites, Antibody; 0/Immunoglobulin A; 0/Immunoglobulin J-Chains; 0/Secretory Component

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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