Document Detail


IgA class anti-beta2-glycoprotein I in patients with systemic lupus erythematosus.
MedLine Citation:
PMID:  9458206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To search for a possible relationship between the presence of IgA class anti-beta2-glycoprotein I antibody (abeta2-GPI) and clinical manifestations, including thrombotic episodes, in patients with systemic lupus erythematosus (SLE). METHODS: Serum IgA abeta2-GPI levels in 124 Japanese patients with SLE were measured using a phospholipid independent enzyme immunoassay. Relationships to clinical histories and to various laboratory data including IgG and IgM class abeta2-GPI were examined. RESULTS: Twenty-five percent of patients with SLE were positive for IgA abeta2-GPI. Patients with a history of thrombosis had significantly higher probabilities for positivity of IgA abeta2-GPI, compared to those without. The presence of IgA abeta2-GPI was correlated with presence of lupus anticoagulant and/or biological false positive result for serological syphilis test. Titer of IgA abeta2-GPI significantly correlated with values of IgG abeta2-GPI, IgM abeta2-GPI, and anti-DNA antibodies. CONCLUSION: The presence of IgA abeta2-GPI may be related to the occurrence of thrombosis in patients with SLE. Measurements of IgA abeta2-GPI may be of value for evaluating risk of thrombosis in patients with SLE.
Authors:
A Tsutsumi; E Matsuura; K Ichikawa; A Fujisaku; M Mukai; T Koike
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  25     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-06     Completed Date:  1998-03-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  74-8     Citation Subset:  IM    
Affiliation:
Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Anticardiolipin / blood
Biological Markers / blood
Glycoproteins / immunology*,  metabolism
Humans
Immunoglobulin A / blood*
Immunoglobulin G / blood
Immunoglobulin M / blood
Lupus Erythematosus, Systemic / blood,  immunology*
Reference Values
beta 2-Glycoprotein I
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Biological Markers; 0/Glycoproteins; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/beta 2-Glycoprotein I
Comments/Corrections
Comment In:
J Rheumatol. 1998 Nov;25(11):2283-4   [PMID:  9818681 ]

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